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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Dec 5, 2025; 16(4): 111104
Published online Dec 5, 2025. doi: 10.4331/wjbc.v16.i4.111104
Published online Dec 5, 2025. doi: 10.4331/wjbc.v16.i4.111104
CD36 fatty-acid-transporter gene variants-CD36 G/A (rs1761667) and CD36 C/T (rs75326924) as biomarkers for risk-prediction in gestational diabetes mellitus
Amreen Shamsad, Tanu Gautam, Monisha Banerjee, Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow 226007, Uttar Pradesh, India
Renu Singh, Department of Obstetrics and Gynecology, King George’s Medical University, Lucknow 226003, Uttar Pradesh, India
Co-first authors: Amreen Shamsad and Tanu Gautam.
Author contributions: Shamsad A and Gautam T have performed the experiments, analysis and prepared the manuscript; Shamsad A and Gautam T designed the experiment, carried out data curation, validation and analysis; Shamsad A, Gautam T and Singh R helped in clinical data collection; Banerjee M supervised, conceptualized, edited, reviewed the manuscript and provided all laboratory facilities; All authors read and approved the final manuscript.
Supported by Maulana Azad National Fellowship, University Grants Commission, New Delhi, Department of Biotechnology, New Delhi, No. AS [82-27/2019 (SA III)]; DBT-BUILDER-University of Lucknow Interdisciplinary Life Science Programme for Advance Research and Education (Level II), No. TG (BT/INF/22/SP47623/2022); and Department of Science and Technology -SERB Power Grant Scheme, No. SPG/2021/00545.
Institutional review board statement: The study was reviewed and approved by the King George’s Medical University (KGMU), Lucknow, India. Institutional Ethical Committee (No. 101st ECM II A/P18 dated May 18, 2020).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Monisha Banerjee, PhD, Professor, Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, University Road, Lucknow 226007, Uttar Pradesh, India. monishabanerjee30@gmail.com
Received: June 24, 2025
Revised: August 12, 2025
Accepted: November 7, 2025
Published online: December 5, 2025
Processing time: 164 Days and 12 Hours
Revised: August 12, 2025
Accepted: November 7, 2025
Published online: December 5, 2025
Processing time: 164 Days and 12 Hours
Core Tip
Core Tip: Gestational diabetes mellitus (GDM) is a metabolic disorder causing hyperglycemia during pregnancy. GDM is associated with adverse feto-maternal outcomes, type-2-diabetes mellitus (T2DM), GDM-recurrence, future obesity. Insulin-resistance is a physiological trait associated with progressing pregnancy that provides an adequate nutritional supply for the mother and fetus. Disruptions in this mechanism might facilitate onset of GDM. CD36-transmembrane glycoprotein receptor, contributes to fatty-acid absorption. Genetic alterations in CD36 gene can modulate expression of genes along these pathways to mitigate the diabetic effect during pregnancy. The integration of genotyping-expression studies will be crucial for advancing investigation in GDM treatment.