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World J Biol Chem. Jun 5, 2026; 17(2): 113144
Published online Jun 5, 2026. doi: 10.4331/wjbc.v17.i2.113144
Published online Jun 5, 2026. doi: 10.4331/wjbc.v17.i2.113144
Study of Tinospora cordifolia stem and Senna siamea leaf and pods: An in vitro therapeutic approach for leukemia
Arthi Boro, Abidharini Jothi Dheivasikamani, Antony Prabhu Jeyabal Philomenathan, Vijaya Anand Arumugam, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641046, Tamil Nādu, India
Jeganathan Manivannan, Department of Environmental Sciences, School of Life Sciences, Bharathiar University, Coimbatore 641046, Tamil Nādu, India
Sujatha Krishnaswamy, Department of Zoology, Government Arts College, Coimbatore 641018, Tamil Nādu, India
Sampathkumar Palanisamy, Department of Chemistry and Biosciences, Shanmugha Arts, Science, Technology and Research Academy, Deemed to be University, Kumbakonam 612001, Tamil Nādu, India
Co-first authors: Arthi Boro and Abidharini Jothi Dheivasikamani.
Author contributions: Boro A designed and performed the experiments, acquired and analyzed the data, and wrote the manuscript; Dheivasikamani AJ and Philomenathan APJ analyzed the data; Manivannan J, Krishnaswamy S, Palanisamy S, and Arumugam VA supervised the study; Boro A and Dheivasikamani AJ played important and indispensable roles in manuscript preparation as the co-first authors; all authors read and approved the final version of the article.
Institutional review board statement: The ethics document is supported by Bharathiar University.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Vijaya Anand Arumugam, Department of Human Genetics and Mole
Received: August 18, 2025
Revised: September 24, 2025
Accepted: January 28, 2026
Published online: June 5, 2026
Processing time: 292 Days and 18.3 Hours
Revised: September 24, 2025
Accepted: January 28, 2026
Published online: June 5, 2026
Processing time: 292 Days and 18.3 Hours
Core Tip
Core Tip: The following study focused on defining the therapeutic properties of aqueous extracts of Tinospora cordifolia stem and Senna siamea pods and leaf in a leukemia cell line. Both plants had therapeutic properties and may be potential treatments for myeloid leukemia, as they induced apoptosis through an increase in reactive oxygen species activity and a reduction in mitochondrial membrane potential. The following study was performed in in vitro and needs further in vivo and clinical studies to confirm our observations.