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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Dec 5, 2025; 16(4): 111110
Published online Dec 5, 2025. doi: 10.4331/wjbc.v16.i4.111110
Published online Dec 5, 2025. doi: 10.4331/wjbc.v16.i4.111110
Dithiothreitol induced endoplasmic reticulum stress and its role in neurodegeneration in Caenorhabditis elegans
Govind Raj, Manish Kumar, Smriti Shreya, Shikha Bhardwaj, Ratna Priya, Department of Zoology, Mahatma Gandhi Central University, Motihari 845401, India
Kailash C Mangalhara, Department of Oncology, Salk Institute for Biological Studies, La Jolla, San Diego, CA 92037, United States
Buddhi Prakash Jain, Gene Expression and Signaling Lab., Department of Zoology, Mahatma Gandhi Central University, Motihari 845401, Bihar, India
Author contributions: Jain BP conceptualized the idea, finally edited the finalized the manuscript; Jain BP and Raj G wrote the manuscript; Raj G performed majority of the experiments; Kumar M and Priya R helped in the experimentation part on C. elegans; Shreya S and Bhardwaj S performed western blotting experiment; Mangalhara KC helped in the editing and revising the manuscript; Jain BP and Priya R performed the revision of the manuscript.
Institutional review board statement: In the present work, no approval from institutional review board is required as the research work was carried out on C. elegans model system.
Conflict-of-interest statement: No conflict of interest.
Data sharing statement: Data will be shared upon request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Buddhi Prakash Jain, Assistant Professor, Gene Expression and Signaling Lab, Department of Zoology, Mahatma Gandhi Central University, Mgcub Motihari, Motihari 845401, Bihar, India. buddhiprakash@mgcub.ac.in
Received: June 26, 2025
Revised: July 16, 2025
Accepted: October 27, 2025
Published online: December 5, 2025
Processing time: 164 Days and 1.8 Hours
Revised: July 16, 2025
Accepted: October 27, 2025
Published online: December 5, 2025
Processing time: 164 Days and 1.8 Hours
Core Tip
Core Tip: Disturbancein the Protein folding process induces Endoplasmic Reticulum Stress and sueseqeunct activation of unfolded Protein Response. accumulation of misfolded or unfolded proteins has been reported in the pathogenesis of several neurodegenerative diseases. Dithiothreitol (DTT), a potent endoplasmic reticulum stress inducer might involve in neurodegenration and related disorders. The present work aims to study the effects of DTT on the unfolded protein response activation and neurobehavioural effects in the Caenorhabditis elegans.