Mohammadi S. Innate immunity and wound repair: The platelet-rich fibrin advantage. World J Biol Chem 2025; 16(2): 107195 [DOI: 10.4331/wjbc.v16.i2.107195]
Corresponding Author of This Article
Saeed Mohammadi, PhD, Assistant Professor, Natural and Medical Sciences Research Center, University of Nizwa, Birkat Al Mouz University of Nizwa Campus, Nizwa 616, Ad Dakhiliyah, Oman. s.mohammadi@unizwa.edu.om
Research Domain of This Article
Immunology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Biol Chem. Jun 5, 2025; 16(2): 107195 Published online Jun 5, 2025. doi: 10.4331/wjbc.v16.i2.107195
Innate immunity and wound repair: The platelet-rich fibrin advantage
Saeed Mohammadi
Saeed Mohammadi, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, Ad Dakhiliyah, Oman
Author contributions: Mohammadi S contributed to this paper, the writing and editing of the manuscript and review of literature, designed the overall concept and outline of the manuscript, read and approved the final version of the manuscript to be published.
Supported by The Oman Ministry of Higher Education, Research, and Innovation, No. BFP/RGP/HSS/24/015.
Conflict-of-interest statement: The author declares that there are no conflicts of interest to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Saeed Mohammadi, PhD, Assistant Professor, Natural and Medical Sciences Research Center, University of Nizwa, Birkat Al Mouz University of Nizwa Campus, Nizwa 616, Ad Dakhiliyah, Oman. s.mohammadi@unizwa.edu.om
Received: March 18, 2025 Revised: April 11, 2025 Accepted: April 27, 2025 Published online: June 5, 2025 Processing time: 73 Days and 15.6 Hours
Abstract
In this editorial, we comment on the article by Sá-Oliveira et al. We focus specifically on the role of platelet-rich fibrin (PRF) in modulating innate immunity to enhance wound repair. The process of wound healing is complex and involves a coordinated series of biological events, including inflammation, cell proliferation, and tissue remodeling. The innate immune system is important in the early stages of wound repair, with inflammation being a crucial initial phase in tissue regeneration. However, the inflammatory response should be regulated, as excessive or dysregulated inflammation can impair healing. Platelet concentrates, specifically PRF, have originated as promising tools to optimize the tissue repair process. PRF is a second-generation platelet concentrate, and the release of growth factors (GFs) plays a determining role in several aspects of wound healing, including promoting cell proliferation, stimulating angiogenesis, and modulating inflammation. PRF forms a fibrin matrix that entraps platelets and GFs. This structure allows for their sustained release over time, which is believed to provide a more favorable microenvironment for tissue repair. Recent research by Sá-Oliveira et al has provided valuable evidence supporting the efficacy of PRF in promoting wound healing. Their study, conducted on an animal model, demonstrated that PRF-based dressings were more effective in accelerating wound closure in the early stages of the healing process, enhancing tissue repair, and modulating the inflammatory response. We explore how PRF's unique properties contribute to a more controlled and effective healing process. By examining these findings, we aim to highlight PRF's potential as a promising therapeutic strategy for improved wound management.
Core Tip: Platelet-rich fibrin (PRF) is a promising autologous blood product for enhanced wound healing. PRF modulates the inflammatory response and promotes tissue regeneration. Recent research highlights PRF's ability to accelerate wound closure, enhance tissue repair, and modulate the inflammatory response in an animal model.
