Naloxone plus enteral nutrition for gastrointestinal dysfunction in elderly cerebral infarction and peptic ulcer patients

Table 1 General information, n (%)

	Control group (n = 55)	Combination group (n = 55)	t/χ2	P value
Gender			0.147	0.702
Male	26 (47.27)	24 (43.64)
Female	29 (52.73)	31 (56.36)
Age (years)	68.23 ± 3.01	67.84 ± 3.24	0.574	0.567
BMI (kg/m2)	22.03 ± 2.42	21.72 ± 2.25	0.700	0.486
Infarction location			0.825	0.843
Brainstem	10 (18.18)	9 (16.36)
Cerebral lobe	14 (25.45)	15 (27.27)
Basal ganglia	29 (52.73)	27 (49.09)
Others	2 (3.64)	4 (7.27)

Table 2 Comparison of National Institute of Health Stroke Scale scores, mean ± SD

Group	NIHSS score
	Before treatment	After treatment
Control group (n = 55)	12.09 ± 2.27	8.73 ± 1.14a
Combination group (n = 55)	12.14 ± 2.62	5.88 ± 1.07a
t value	0.039	12.270
P value	0.969	< 0.001

^aP < 0.05 vs the group before treatment.

NIHSS: National Institute of Health Stroke Scale.

Table 3 Comparison of daily activities and quality of life, mean ± SD

Group	BI		SF-36 score
	Before treatment	After treatment	Before treatment	After treatment
Control group (n = 55)	51.23 ± 3.01	72.29 ± 3.23a	35.83 ± 9.04	70.21 ± 3.66a
Combination group (n = 55)	51.18 ± 3.74	87.36 ± 4.42a	36.01 ± 9.10	76.26 ± 3.85a
t value	0.056	20.480	0.074	8.508
P value	0.955	< 0.001	0.941	< 0.001

^aP < 0.05 vs the group before treatment.

BI: Barthel Index; SF-36: MOS 36-Item Short Form Health Survey.

Table 4 Comparison of gastrointestinal dysfunction scores, mean ± SD

Group	Gastrointestinal dysfunction score
	Before treatment	After treatment
Control group (n = 55)	12.26 ± 3.02	8.62 ± 1.31a
Combination group (n = 55)	12.41 ± 2.97	5.14 ± 1.27a
t value	0.479	13.660
P value	0.633	< 0.001

^aP < 0.05 vs the group before treatment.

Table 5 Serum gastrointestinal hormone levels in the two groups, mean ± SD

Group	MTL (ng/L)		GAS (pg/mL)		SS (pg/mL)
	Before treatment	After treatment	Before treatment	After treatment	Before treatment	After treatment
Control group (n = 55)	117.95 ± 10.31	186.81 ± 11.18a	69.18 ± 12.38	103.15 ± 10.52a	9.21 ± 1.66	8.31 ± 1.19a
Combination group (n = 55)	118.02 ± 10.29	201.31 ± 12.35a	68.71 ± 12.44	94.46 ± 9.64a	9.17 ± 1.42	5.69 ± 1.25a
t value	0.033	6.453	0.198	4.514	0.140	11.270
P value	0.974	< 0.001	0.843	< 0.001	0.889	< 0.001

^aP < 0.05 vs the group before treatment.

MTL: Motilin; GAS: Gastrin; SS: Somatostatin.