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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jan 27, 2026; 18(1): 115201
Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.115201
Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.115201
Naloxone plus enteral nutrition for gastrointestinal dysfunction in elderly cerebral infarction and peptic ulcer patients
Xin-Xin Chen, Department of Internal Medicine, Tsinghua University Hospital, Beijing 100084, China
Xue-Fei Han, Department of Geriatric, Beijing Xicheng District Pingan Hospital, Beijing 100071, China
Yan Chu, Department of Neurology I, Huai'an Clinical Medical College of Jiangsu University Huai'an Hospital of Huai'an City, Huai’an 223200, Jiangsu Province, China
Author contributions: Chen XX and Han XF contributed to research design, data collection, data analysis, and paper writing; Chu Y was responsible for research design, funding application, data analysis, reviewing and editing, communication coordination, ethical review, copyright and licensing, and follow-up.
Institutional review board statement: The research was reviewed and approved by the Medical Ethics Committee of Huai'an Clinical Medical College of Jiangsu University Huai'an Hospital of Huai'an City.
Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.
Conflict-of-interest statement: No conflict of interest is associated with this work.
Data sharing statement: No other data available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Chu, Associate Chief Physician, Department of Neurology I, Huai'an Clinical Medical College of Jiangsu University Huai'an Hospital of Huai'an City, No. 19 Shanyang Avenue, Huai’an 223200, Jiangsu Province, China. 15195340997@163.com
Received: October 10, 2025
Revised: November 5, 2025
Accepted: November 27, 2025
Published online: January 27, 2026
Processing time: 103 Days and 1.7 Hours
Revised: November 5, 2025
Accepted: November 27, 2025
Published online: January 27, 2026
Processing time: 103 Days and 1.7 Hours
Core Tip
Core Tip: This study investigates the combined effect of naloxone and enteral nutrition (EN) on alleviating gastrointestinal dysfunction in elderly patients with cerebral infarction (CI) and peptic ulcers. With CI being prevalent among the elderly and often accompanied by gastrointestinal complications, the research aims to provide evidence supporting the use of naloxone, an opioid receptor antagonist, alongside EN to improve gastrointestinal health and promote recovery.