Prognostic significance of advanced lung cancer inflammation index in resectable pancreatic cancer: A retrospective study

Table 1 Clinical characteristics

Characteristic	n = 611
Age (years)	60.7 ± 9.3
Sex
Male	344 (56.3)
Female	267 (43.7)
Body mass index (kg/m2)	23.5 ± 3.3
Smoking	148 (24.2)
Drinking	109 (17.8)
Hypertension	173 (28.3)
Type 2 diabetes mellitus	177 (29.0)
Albumin (g/L)	41.8 ± 5.6
Neutrophils (× 109/L)	4.2 ± 2.0
Lymphocytes (× 109/L)	1.6 ± 0.6
Advanced lung cancer inflammation index	44.0 ± 23.5
Tumor location
Pancreatic head and neck	315 (51.6)
Pancreatic body and tail	296 (48.4)
TNM stage
I	306 (50.1)
II	158 (25.9)
III	147 (24.1)
Tumor size (cm)	3.8 ± 1.6
Operation time (min)	251.0 ± 112.0
Blood loss (mL)	411.7 ± 476.4
Hospital stays (days)	16.8 ± 10.3

Variables are expressed as the mean ± SD, n (%).

Table 2 Baseline information between high advanced lung cancer inflammation index group and low advanced lung cancer inflammation index group

Characteristic	Low ALI (n = 233)	High ALI (n = 378)	P value
Age (years)	61 + 12	62 + 11	0.508
Sex			0.418
Male	136 (58.4)	208 (55.0)
Female	97 (41.6)	170 (45.0)
Body mass index (kg/m2)	22.7 + 3.9	23.7 + 4.3	< 0.01
Smoking	54 (23.2)	94 (24.9)	0.635
Drinking	35 (15.0)	74 (19.6)	0.153
Hypertension	76 (32.6)	97 (25.7)	0.064
Type 2 diabetes mellitus	67 (28.8)	110 (29.1)	0.927
Albumin (g/L)	41.0 + 7	42.6 + 6.2	< 0.01
Neutrophils (× 109/L)	4.7 + 2.3	3.4 + 1.4	< 0.01
Lymphocytes (× 109/L)	1.2 + 0.5	1.8 + 0.7	< 0.01
ALI	24.7 + 10.9	50.1 + 24.0	< 0.01
Tumor location			< 0.01
Pancreatic head and neck	143 (61.4)	172 (45.5)
Pancreatic body and tail	90 (38.6)	206 (54.5)
TNM stage			0.691
I	116 (49.8)	190 (50.3)
II	57 (24.5)	101 (26.7)
III	60 (25.8)	87 (23.0)
Tumor size	3.5 + 1.9	3.5 + 2	0.830

Continuous variables are expressed as median and interquartile range, n (%). ALI: Advanced lung cancer inflammation index.

Table 3 Outcomes between high advanced lung cancer inflammation index group and low advanced lung cancer inflammation index group

Characteristic	Low ALI (n = 233)	High ALI (n = 378)	P value
Operation time (min)	260.0 + 150.0	219.5 + 147.8	< 0.01
Intraoperative blood loss (mL)	300.0 + 500.0	200.0 + 500.0	0.248
Postoperative hospital stays (days)	14.0 + 9.0	14.0 + 10.0	0.207

Continuous variables are expressed as median and interquartile range. ALI: Advanced lung cancer inflammation index.

Table 4 Univariate and multivariate analysis of overall survival

Risk factor	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age (years)	1.012 (1.001-1.023)	0.029	1.015 (1.005-1.026)	< 0.01
Sex (male/female)	0.844 (0.691-1.031)	0.097
Smoking (yes/no)	1.157 (0.919-1.456)	0.214
Drinking (yes/no)	1.026 (0.852-1.234)	0.789
Hypertension (yes/no)	1.128 (0.903-1.409)	0.289
Type 2 diabetes mellitus (yes/no)	1.186 (0.954-1.473)	0.123
Tumor location (body and tail/head and neck)	1.028 (0.843-1.252)	0.787
Tumor stage (III/II/I)	1.265 (1.122-1.426)	< 0.01	1.240 (1.092-1.407)	< 0.01
Tumor size (cm)	1.093 (1.036-1.154)	< 0.01	1.069 (1.010-1.131)	0.022
Advanced lung cancer inflammation index (high/Low)	0.765 (0.625-0.935)	< 0.01	0.784 (0.641-0.960)	0.018

HR: Hazard ratio.