Clinical efficacy of neoadjuvant chemotherapy combined with radical gastrectomy in elderly patients with advanced gastric cancer

Table 1 Comparison of baseline data between two groups of gastric cancer patients (cases)

Clinical indicators	Number of cases	Middle aged and young group (n = 111)	Elderly group (n = 37)	χ2 value	P value
Gender				0.062	0.803
Female	26	20	6	-	-
Male	122	91	31	0.885	0.347
Underlying disease
No	105	81	24	-	-
Yes	43	30	13	-	-
BMI (kg/m2), mean ± SD	-	22.9 ± 4.3	21.9 ± 2.7	1.369	0.245
Tumor site				0.997	0.607
Upper part of stomach	94	69	25
Middle part of stomach	19	16	3
Lower part of stomach	35	26	9
Clinical stages				0.022	0.882
Phase II	17	13	4
Phase III	131	98	33
Neoadjuvant chemotherapy regimen				4.214	0.239
FOLFOX	81	66	15
SOX	55	37	18
XELOX	7	5	2
FLOT	5	3	2
Neoadjuvant chemotherapy cycle				0.225	0.635
< 3	73	56	17
≥ 3	75	55	20
Operation				0.580	0.446
Laparoscope	80	58	22
Openness	68	53	15
Postoperative chemotherapy				0.379	0.538
No	46	33	13
Yes	102	78	24

BMI: Body mass index; FOLFOX: Fluorouracil, leucovorin, and oxaliplatin; SOX: Sex-determining region Y-box; XELOX: Capecitabine and oxaliplatin; FLOT: Fluorouracil, leucovorin, oxaliplatin, taxotere.

Table 2 Comparison of common terminology criteria for adverse events grading of complications in neoadjuvant chemotherapy between two groups of gastric cancer patients (cases)

Non hematological complications	Middle aged and young group (n = 111)	Elderly group (n = 37)	χ2 value	P value
New hematological complications
Level 3-4	3	4	-	0.066
Anemia	20	8	0.235	0.628
Level 1-2	18	7	-	-
Level 3-4	2	1	-	-
Leukopenia	40	16	0.613	0.434
Level 1-2	40	16	-	-
Level 3-4	0	0	-	-
Neutropenia	34	11	0.011	0.918
Level 1-2	33	9	-	-
Level 3-4		2	-	-
Thrombocytopenia	9	4	0.253	0.615
Level 1-2	9	3	-	-
Level 3-4	0	1	-	-
Non hematological complications
Level 3-4	14	9	2.900	0.089
Nausea	36	13	0.092	0.762
Level 1-2	28	10	-	-
Level 3-4	8	3	-	-
Vomit	15	6	0.166	0.683
Level 1-2	10	4	-	-
Level 3-4	5	2	-	-
Diarrhea	20	7	0.015	0.902
Level 1-2	16	5	-	-
Level 3-4	4	2	-	-
Mucositis	12	5	0.199	0.766
Level 1-2	9	3	-	-
Level 3-4	3	2	-	-

Table 3 Comparison of Clavien-Dindo grading for postoperative complications in two groups of gastric cancer patients (cases)

Non hematological complications	Middle aged and young group (n = 111)	Elderly group (n = 37)	χ2 value	P value
Clavien-Dindo grading			2.926	0.232
Level 0	83	23	-	-
Level 1-2	21	12	-	-
Level 3-4	7	2	-	-
Postoperative complications
Pleural effusion	4	6	7.007	0.008
pulmonary infection	8	10	10.204	0.001
pneumothorax	1	1		0.439
Acute respiratory distress syndrome	3	0		0.573
Gastroparesis	2	-	-	1
Intestinal obstruction	3	0	-	0.573
Complications of anastomotic site	3	1	-	1.000
Abdominal bleeding	l	0	-	1.000
Wound infection	3	0	-	0.573
Cardiovascular and cerebrovascular related complications	4	3	-	0.264