Wei LL, Lai YL, Qiu KH, He X, Yang T. Clinical efficacy of neoadjuvant chemotherapy combined with radical gastrectomy in elderly patients with advanced gastric cancer. World J Gastrointest Surg 2025; 17(9): 106995 [DOI: 10.4240/wjgs.v17.i9.106995]
Corresponding Author of This Article
Tao Yang, Department of Dermatology, First Affiliated Hospital of Gannan Medical University, No. 130 Zhangjiang North Avenue, Zhanggong District, Ganzhou 341000, Jiangxi Province, China. danny20021068@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Sep 27, 2025; 17(9): 106995 Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.106995
Clinical efficacy of neoadjuvant chemotherapy combined with radical gastrectomy in elderly patients with advanced gastric cancer
Liu-Liu Wei, Yue-Liang Lai, Kang-Hua Qiu, Xin He, Tao Yang
Liu-Liu Wei, Yue-Liang Lai, Kang-Hua Qiu, Department of Gastroenterology, Ganzhou People’s Hospital, Ganzhou 341000, Jiangxi Province, China
Xin He, Department of Oncology, Tangdu Hospital of Air Force Medical University, Xi’an 710038, Shaanxi Province, China
Tao Yang, Department of Dermatology, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
Co-corresponding authors: Xin He and Tao Yang.
Author contributions: Wei LL and Lai YL collected and analyzed data and drafted the manuscript; Qiu KH contributed to study design and patient enrollment; He X provided critical revisions; He X and Yang T supervised the study, they contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Tangdu Hospital of Air Force Medical University, approval No. 2024070385.
Informed consent statement: This retrospective study was conducted using anonymized clinical data without direct patient interaction. The requirement for written informed consent was waived by the Ethics Committee of Tangdu Hospital due to the retrospective nature of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets used and analyzed during the current study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tao Yang, Department of Dermatology, First Affiliated Hospital of Gannan Medical University, No. 130 Zhangjiang North Avenue, Zhanggong District, Ganzhou 341000, Jiangxi Province, China. danny20021068@126.com
Received: April 18, 2025 Revised: June 4, 2025 Accepted: July 11, 2025 Published online: September 27, 2025 Processing time: 159 Days and 0 Hours
Core Tip
Core Tip: Neoadjuvant chemotherapy combined with radical gastrectomy is a safe and effective treatment for elderly patients with advanced gastric cancer. Despite the increased risk of pulmonary complications, such as pleural effusion and pulmonary infection, postoperative recovery time and survival outcomes are similar to younger patients. Hematological and non-hematological complications related to chemotherapy are generally manageable. While age-related factors may affect chemotherapy tolerance, the combination therapy significantly improves surgical resectability and prognosis. Close monitoring of renal function and attention to pulmonary and cardiovascular issues are crucial for optimizing treatment outcomes in elderly gastric cancer patients.
