Genetically engineered mouse models in gastric precancerous lesions research

Table 1 Genetically engineered mouse models of precancerous lesions of gastric cancer

Models	Time/lesions	Subtype	Method	Genetic background	Location	Reference
INS-GAS	12 months	IM; D	Transgenic mouse + H. felis	C57BL/6	Corpus	[13]
INS-GAS	5 months	D	Transgenic mouse + H. pylori	FVB/N	Corpus/antrum	[14]
INS-GAS	6 months	D	Transgenic mouse + H. pylori	FVB/N	Corpus	[10]
INS-GAS	4 months	IM; D	Transgenic mouse + H. pylori	FVB/N	Corpus	[15]
Gastrin-/-	12 months	D	Knockout mouse + H. felis	C57Bl/6	Antrum	[13]
Gastrin-/-	9 months	D	Knockout mouse	129/Sv-C57/BL6	Antrum	[20]
Atp4a (-/-)	3 months	IM	Knockout mouse	C57Bl/6	Antrum	[28]
Atp4a (-/-)	3 months	D	Knockout mouse	129SvJ/ Black Swiss	/	[26]
Atp4b (-/-)	12 months	SPEM	Knockout mouse	BalbC	Corpus	[33]
Slc26a9	6 months	SPEM; IM	Knockout mouse	S129/svj	/	[37]
H+/K+ -IFN-γ	3 months	D	Transgenic mouse	H+/K+ -IFN-γ944	Corpus	[39]
K19-IL11Tg	3 months	A	Transgenic mouse	C57BL/ 6J / DBA/2J	Corpus	[43]
Gp130 757F/F	1 months	D	Knock in mouse	129 Sv-J/C57BL/6	Antrum	[97]
H+/K+-ATPase-IL-1β	12 months	D	Transgenic mouse	C57BL/6J	Corpus	[50]
Mist1-Kras	3 months	IM	Transgenic mouse	C57BL/6J	Corpus	[54]
K19-Kras	3 months	A; IM; D	Transgenic mouse	C57BL/6	Corpus	[53]
Car9-/-	5 months	A	Knockout mouse	C57BL/6	Corpus	[58]
CDX1	120 days	IM	Transgenic mouse	C57BL/6	Corpus	[63]
Foxa3-CDX2	1 months	IM	Transgenic mouse	C57BL/6J	Corpus	[98]
CDX2	37 days	IM	Transgenic mouse	C57BL/6J	Corpus	[64]
Apcmin+	6 months	A; IM; D	Point mutation mouse	C57BL/6J	Corpus/antrum	[74]
TFF1-/-	6 months	D	Knockout mouse	C57BL/6J/129/Sv	Antrum	[99]
TFF1-/-	6 months	D	Knockout mouse	C57BL/6J/129/Sv	Antrum	[78]
CLDN18-/-	3 days	A	Knockout mouse	/	Corpus	[83]
Bak-/-	12 months	D	Knockout mouse + H. felis	C57BL/6	Corpus	[88]

IFN-γ: Interferon-γ; SPEM: Spasmolytic polypeptide-expressing metaplasia; IM: Intestinal metaplasia; H. pylori: Helicobacter pylori; H. felis: Helicobacter felis.