Quan Y, Jia YB, Wu CH, Jia QL, Chen YQ, Gu ZJ, Ling JH. Genetically engineered mouse models in gastric precancerous lesions research. World J Gastrointest Surg 2025; 17(7): 107610 [DOI: 10.4240/wjgs.v17.i7.107610]
Corresponding Author of This Article
Jiang-Hong Ling, MD, Professor, Department of Gastroenterology, Shuguang Affiliated Hospital, Shanghai University of Traditional Chinese Medicine, No. 185 Pu’an Road, Huangpu District, Shanghai 200021, China. 459183870@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Opinion Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yi Quan, Yue-Bo Jia, Chen-Heng Wu, Qing-Ling Jia, Zhi-Jian Gu, Jiang-Hong Ling, Department of Gastroenterology, Shuguang Affiliated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China
Yong-Qi Chen, Department of Pathology, Shuguang Affiliated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China
Co-first authors: Yi Quan and Yue-Bo Jia.
Co-corresponding authors: Zhi-Jian Gu and Jiang-Hong Ling.
Author contributions: Quan Y and Jia YB designed the study, drafted the original manuscript, they contributed equally to this article, they are the co-first authors of this manuscript; Wu CH, Jia QL, and Gu ZJ contributed to make significant revisions to the thesis; Wu CH and Chen YQ contributed to make the table; Wu CH, Gu ZJ, and Ling JH contributed to fund; Ling JH contributed to approval of the final version and quality of the paper for publication; Gu ZJ and Ling JH contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the National Administration of Traditional Chinese Medicine National Superior Specialty Project of Traditional Chinese Medicine, No. [2024] 90; Shanghai Municipal Administrator of Traditional Chinese Medicine Policy Letter [2024], No. 20; Science and Technology Development Fund of Shanghai University of Traditional Chinese Medicine, No. 23KFL102; and Shuguang Hospital Siming Foundation Research Special Project, No. SGKJ-202304.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jiang-Hong Ling, MD, Professor, Department of Gastroenterology, Shuguang Affiliated Hospital, Shanghai University of Traditional Chinese Medicine, No. 185 Pu’an Road, Huangpu District, Shanghai 200021, China. 459183870@qq.com
Received: March 28, 2025 Revised: April 20, 2025 Accepted: June 6, 2025 Published online: July 27, 2025 Processing time: 118 Days and 3.9 Hours
Abstract
Precancerous lesions of gastric cancer (PLGC) are crucial for the progression to gastric cancer, and early intervention in PLGC is pivotal in preventing its development into gastric cancer. In order to illustrate the molecular mechanisms underlying PLGC and the roles of associated genes within these lesions, genetically engineered mouse models (GEMMs) have been developed. We systematically summarize the current GEMMs, and highlight the principal pathological mechanisms involved, including gastrin/gastric acid balance, inflammatory factors, the interplay between cancer-promoting and cancer-suppressing genes, and apoptotic pathways. We further discuss the mechanisms involved in the existing GEMMs of PLGC.
Core Tip: Precancerous lesions of gastric cancer refer to a series of pathological changes in the gastric mucosa, including atrophic gastritis, intestinal metaplasia, and dysplasia. These lesions are significant risk factors for the development of gastric carcinoma. Genetically engineered mice, modified through techniques such as gene knockout, gene knock-in, transgenesis, and point mutation, are utilized to investigate gene function, disease mechanisms, and to develop novel therapeutic strategies. This review discusses the genetically engineered mouse models employed in the study of precancerous lesions of gastric cancer, with an emphasis on elucidating their pathological mechanisms.
