MicroRNA 195, lactate dehydrogenase 5, phosphatase and tensin homologue in colorectal cancer: Clinicopathology and prognosis

Table 1 The microRNA 195, lactate dehydrogenase-5, and phosphatase and tensin homologue expression in colorectal cancer tissues and adjacent normal tissues, n (%)

Group	miR195		LDH-5		PTEN
	Positive	Negative	Positive	Negative	Positive	Negative
CRC tissues (n = 53)	19 (35.85)	34 (64.15)	42 (79.25)	11 (20.75)	15 (28.30)	38 (71.70)
Adjacent normal tissues (n = 53)	48 (90.57)	5 (9.43)	6 (11.32)	47 (88.68)	50 (94.34)	3 (5.66)
χ2	34.116		49.345		48.724
P value	< 0.001		< 0.001		< 0.001

CRC: Colorectal cancer; miR195: MicroRNA 195; LDH-5: Lactate dehydrogenase-5; PTEN: Phosphatase and tensin homologue.

Table 2 Correlation of microRNA 195, lactate dehydrogenase-5, and phosphatase and tensin homologue expression with clinicopathological features, n (%)

Clinical features	Factors	n	miR195		χ2	P value	LDH-5		χ2	P value	PTEN		χ2	P value
			Positive (n = 19)	Negative (n = 34)			Positive (n = 42)	Negative (n = 11)			Positive (n = 15)	Negative (n = 38)
Sex	Male	30	11 (36.67)	19 (63.33)	0.020	0.887	22 (73.33)	8 (26.67)	1.469	0.225	9 (30.00)	21 (70.00)	0.098	0.754
	Female	23	8 (34.78)	15 (65.22)			20 (86.96)	3 (13.04)			6 (26.09)	17 (73.91)
Age, years	≥ 50	24	9 (37.50)	15 (62.50)	0.052	0.820	18 (75.00)	6 (25.00)	0.481	0.488	9 (37.50)	15 (62.50)	1.829	0.176
	< 50	29	10 (34.48)	19 (65.52)			24 (82.76)	5 (17.24)			6 (20.69)	23 (79.31)
Tumor site	Colon	28	12 (42.86)	16 (57.14)	1.268	0.260	21 (75.00)	7 (25.00)	0.651	0.420	7 (25.00)	21 (75.00)	0.319	0.572
	Rectum	25	7 (28.00)	18 (72.00)			21 (84.00)	4 (16.00)			8 (32.00)	17 (68.00)
TNM stage	I–II	21	13 (61.90)	8 (38.10)	10.268	0.001	13 (61.90)	8 (38.10)	6.359	0.012	8 (38.10)	13 (61.90)	1.644	0.200
	III–IV	32	6 (18.75)	26 (81.25)			29 (90.63)	3 (9.38)			7 (21.88)	25 (78.13)
Tumor diameter, cm	≥ 2	23	5 (21.74)	18 (78.26)	3.512	0.061	16 (69.57)	7 (30.43)	2.315	0.128	3 (13.04)	20 (86.96)	4.662	0.031
	< 2	30	14 (46.67)	16 (53.33)			26 (86.67)	4 (13.33)			12 (40.00)	18 (60.00)
Differentiation degree	Well and moderately	36	16 (44.44)	20 (55.56)	3.601	0.058	25 (69.44)	11 (30.56)	6.555	0.010	12 (33.33)	24 (66.67)	1.400	0.237
	Poorly	17	3 (17.65)	14 (82.35)			17 (100.00)	0 (0)			3 (17.65)	14 (82.35)
Lymph node metastasis	Presence	29	5 (17.24)	24 (82.76)	9.642	0.002	27 (93.10)	2 (6.90)	7.478	0.006	4 (13.79)	25 (86.21)	6.644	0.010
	Absence	24	14 (58.33)	10 (41.67)			15 (62.50)	9 (37.50)			11 (45.83)	13 (54.17)

miR195: MicroRNA 195; LDH-5: Lactate dehydrogenase-5; PTEN: Phosphatase and tensin homologue; TNM: Tumor, node, metastasis.

Table 3 Relationship among microRNA 195, lactate dehydrogenase-5, and phosphatase and tensin homologue in colorectal cancer tissues

Indicator	miR195		LDH-5
	r	P value	r	P value
miR195	-	-	-0.883	0.015
LDH-5	-0.883	0.015	-	-
PTEN	0.429	0.006	-0.396	< 0.001

miR195: MicroRNA 195; LDH-5: Lactate dehydrogenase-5; PTEN: Phosphatase and tensin homologue.