Tang Z, Wen LM. MicroRNA 195, lactate dehydrogenase 5, phosphatase and tensin homologue in colorectal cancer: Clinicopathology and prognosis. World J Gastrointest Surg 2025; 17(7): 107121 [DOI: 10.4240/wjgs.v17.i7.107121]
Corresponding Author of This Article
Li-Ming Wen, Chief Physician, Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, No. 319 Section 3, Zhongshan Road, Luzhou 646000, Sichuan Province, China. wenlm404@yeah.net
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jul 27, 2025; 17(7): 107121 Published online Jul 27, 2025. doi: 10.4240/wjgs.v17.i7.107121
MicroRNA 195, lactate dehydrogenase 5, phosphatase and tensin homologue in colorectal cancer: Clinicopathology and prognosis
Zuo Tang, Li-Ming Wen
Zuo Tang, Li-Ming Wen, Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
Zuo Tang, Li-Ming Wen, Department of Gastroenterology, Mianyang 404 Hospital, Mianyang 621000, Sichuan Province, China
Author contributions: Tang Z and Wen LM designed the research study; Tang Z performed the research and collected the data; Tang Z and Wen LM analyzed the data and wrote the manuscript; Both authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Mianyang 404 Hospital, Approval No. 2022-MY01002.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Ming Wen, Chief Physician, Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, No. 319 Section 3, Zhongshan Road, Luzhou 646000, Sichuan Province, China. wenlm404@yeah.net
Received: March 21, 2025 Revised: April 20, 2025 Accepted: May 28, 2025 Published online: July 27, 2025 Processing time: 124 Days and 2.7 Hours
Core Tip
Core Tip: Colorectal cancer (CRC) incidence has shown a sustained annual increase with a notable trend toward younger-onset cases, significantly affecting public health. In this retrospective cohort study, we systematically conducted clinical data of 53 CRC patients, performing quantitative comparison of microRNA 195 (miR195), lactate dehydrogenase-5 (LDH-5), and phosphatase and tensin homologue (PTEN) expression profiles between tumor tissues and matched adjacent normal tissues, as well as their correlation with clinicopathological parameters and prognosis. Our findings revealed that reduced miR195 and PTEN expression, coupled high LDH-5 expression exhibited strong mechanistic associations with CRC pathogenesis and disease progression, suggesting that molecular alterations as potential utility as a novel diagnostic indicators for precision oncology applications.
