Control observation of different digestive tract reconstruction methods in total gastrectomy for gastric cancer

Table 1 Analysis of the baseline characteristics’ balance, mean ± SD/n (%)

General information	A group (n = 90)	B group (n = 82)	t/χ2	P value
Age (years)	65.9 ± 8.1	63.8 ± 7.6	1.749	0.082
BMI (kg/m2)	22.25 ± 2.20	22.45 ± 2.15	-0.602	0.548
Gender			0.268	0.604
Male	54 (60.00)	46 (56.1)
Female	36 (40.00)	36 (43.9)
Smoking			3.083	0.079
Yes	32 (35.56)	40 (48.78)
No	58 (64.44)	42 (51.22)
Tipple			1.995	0.158
Yes	28 (31.11)	34 (41.46)
No	62 (68.89)	48 (58.54)
TNM stage			2.892	0.089
I + II stage	61(67.78)	65 (79.27)
III stage	29 (32.22)	17 (20.73)
Focal diameter			2.2	0.138
≤ 3.0 cm	43 (47.78)	30 (36.59)
> 3.0 cm	47 (52.22)	52 (63.41)
Degree of tumor differentiation			2.393	0.122
High + medium differentiation	62 (68.89)	65 (79.27)
Poorly differentiated	28 (31.11)	17 (20.73)
Lymph node metastasis			3.123	0.077
Yes	38 (42.22)	24 (29.27)
No	52 (57.78)	58 (70.73)

BMI: Body mass index; TNM: Tumor node metastasis.

Table 2 Comparison of surgical procedure indicators between the two groups of patients, mean ± SD

Group	n	Operation time (minutes)	Digestive tract reconstruction time (minutes)	Operative blood loss (mL)	Anal first exhaust time (hour)	Average length of stay (day)
A group	90	167.5 ± 14.3	24.8 ± 5.1	240.4 ± 48.1	46.9 ± 12.0	12.4 ± 2.4
B group	82	170.8 ± 17.2	27.0 ± 4.8	245.8 ± 43.7	45.1 ± 9.8	12.9 ± 2.8
t		-1.373	-2.906	-0.768	1.071	-1.261
P value		0.172	0.004	0.444	0.286	0.209

Table 3 Comparison of laboratory indicators related to gastrointestinal barrier function between the two groups, mean ± SD

Group	n	D-lactic acid (mg/L)		DAO (IU/L)		ETX (EU/mL)
		Before operation	Postoperative 3 days	Before operation	Postoperative 3 days	Before operation	Postoperative 3 days
A group	90	2.43 ± 0.50	3.27 ± 0.61a	1.52 ± 0.40	2.11 ± 0.48a	0.41 ± 0.08	1.10 ± 0.21a
B group	82	2.30 ± 0.48	3.56 ± 0.67a	1.44 ± 0.45	2.24 ± 0.55a	0.43 ± 0.11	1.16 ± 0.24a
t		1.736	-2.971	1.234	-1.655	-1.372	-1.748
P value		0.084	0.003	0.219	0.100	0.172	0.082

^aP < 0.05.

P values compared with the preoperative group. DAO: Diamine oxidase; ETX: Endotoxin.

Table 4 Comparison of nutritional indicators between the two groups of patients, mean ± SD

Group	n	PNI		ALB (g/L)
		Before operation	One month after surgery	Before operation	One month after surgery
A group	90	55.91 ± 4.02	45.71 ± 4.00a	39.41 ± 3.44	35.10 ± 2.85a
B group	82	57.03 ± 5.18	43.31 ± 4.58a	40.42 ± 3.95	33.91 ± 3.02a
t		-1.592	3.668	-1.792	2.658
P value		0.113	0.000	0.075	0.009
Group	n	TP (g/L)		Body mass (kg)
		Before operation	One month after surgery	Before operation	One month after surgery
A group	90	70.33 ± 4.03	64.62 ± 3.96a	64.31 ± 5.30	61.80 ± 4.71a
B group	82	71.40 ± 4.55	63.70 ± 4.03a	65.88 ± 5.51	60.73 ± 4.48a
t		-1.635	1.509	-1.904	1.523
P value		0.104	0.133	0.059	0.130

^aP < 0.05.

P values compared with the preoperative group. PNI: Prognostic nutritional index; ALB: Albumin; TP: Total protein.

Table 5 Comparison of immunological indicators between the two groups of patients, mean ± SD

Group	n	CD3 + (%)		CD4 + (%)		CD8 + (%)
		Before operation	One month after surgery	Before operation	One month after surgery	Before operation	One month after surgery
A group	90	63.20 ± 5.10	56.13 ± 4.77a	42.30 ± 4.46	38.37 ± 4.09a	24.42 ± 2.66	28.30 ± 2.96a
B group	82	64.51 ± 5.37	54.92 ± 4.40a	43.17 ± 4.85	37.45 ± 4.76a	25.07 ± 3.00	29.16 ± 3.05a
t		-1.641	1.724	-1.226	1.363	-1.506	-1.876
P value		0.103	0.087	0.222	0.175	0.134	0.062

^aP < 0.05.

P values compared with the preoperative group. CD: Cluster of differentiation.

Table 6 Comparison of complication rates between the two groups of patients, n (%)

Group	n	Anastomotic fistula	Reflux esophagitis	Anastomotic ulcer	Diarrhea	Ileus	Complication rate
A group	90	2	2	0	4	1	9 (10.00)
B group	82	4	5	2	6	3	20 (24.39)
χ2							6.339
P value							0.012