ANXA13 expression patterns in hepatocellular carcinoma and impact on tumor behavior

doi:10.4240/wjgs.v17.i10.111673

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Oct 27, 2025 (publication date) through Oct 24, 2025

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Oct 27, 2025; 17(10): 111673
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.111673

Table 1 Expression of ANXA13 protein in 50 related tissue specimens

Group	Number of cases	*ANXA13/GAPDH*	P value
HCC tissue	50	1.466 ± 0.1753	< 0.05
Adjacent normal tissue	50	1.000 ± 0.0000

HCC: Hepatocellular carcinoma.

Full Size Table

Table 2 ANXA13 positive staining intensity H-score evaluation results

Group	Number of cases	H-score (mean ± SD)
HCC tissue	48	99.83 ± 11.00
Adjacent normal tissue	48	51.50 ± 15.13

HCC: Hepatocellular carcinoma.

Full Size Table

Table 3 Correlation between ANXA13 gene expression and clinicopathological data characteristics of liver cancer patients

Characteristics	Case	High expression	Low expression	P value	χ²
Age
> 60	28	14	14	0.493	0.470
< 60	20	8	12
Sex
Male	37	18	19	0.473	0.515
Female	11	4	7
Grade
I-II	11	6	5	0.635	0.907
III	28	13	15
IV	9	3	6
Diameter
> 5 cm	41	22	19	0.026^a	4.941
< 5 cm	7	0	7
TNM stage
I+II	24	7	17	0.020^a	5.371
III+IV	24	15	9

^aP < 0.05.

TNM: Tumor node metastasis.

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Citation: Yang SK, Zhao XK, Cui YY, Liu DZ, Zhao ZJ, Zhou L, Wang L, Zhang F. ANXA13 expression patterns in hepatocellular carcinoma and impact on tumor behavior. World J Gastrointest Surg 2025; 17(10): 111673
URL: https://www.wjgnet.com/1948-9366/full/v17/i10/111673.htm
DOI: https://dx.doi.org/10.4240/wjgs.v17.i10.111673