Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Oct 27, 2025; 17(10): 111673
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.111673
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.111673
ANXA13 expression patterns in hepatocellular carcinoma and impact on tumor behavior
Shu-Kuan Yang, Yang-Yang Cui, De-Zheng Liu, Zi-Jian Zhao, Lei Zhou, Fan Zhang, Department of Biliary-Pancreatic Surgery, The Affiliated Hospital of Binzhou Medical University, Binzhou 256603, Shandong Province, China
Xue-Kai Zhao, Department of General Surgery, Binzhou People's Hospital, Binzhou 256600, Shandong Province, China
Lin Wang, Department of Ophthalmology, The Affiliated Hospital of Binzhou Medical University, Binzhou 256603, Shandong Province, China
Author contributions: Yang SK and Zhou L designed the study; Yang SK, Zhao XK and Wang L performed the experiments, acquired and analyzed data; Yang SK, Zhao XK, Liu DZ, Zhao ZJ and Zhang F interpreted the data; Yang SK wrote the manuscript; all authors approved the final version of the article.
Supported by The Natural Science Foundation of China, No. 31640052; and the Natural Science Fund Project of Shandong Province, No. ZR2019BH031.
Institutional review board statement: The study was reviewed and approved by the Research Ethics Committee of Binzhou Medical University Hospital (No. KYLL-336).
Conflict-of-interest statement: The author reports no conflicts of interest in this work.
Data sharing statement: The data that support the findings of this study are available on request from the corresponding author, Lei Zhou, upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei Zhou, MD, Full Professor, Department of Biliary-Pancreatic Surgery, The Affiliated Hospital of Binzhou Medical University, No. 661 Huanghe 2nd Road, Binzhou 256603, Shandong Province, China. dr_zhlei@163.com
Received: July 7, 2025
Revised: August 5, 2025
Accepted: August 21, 2025
Published online: October 27, 2025
Processing time: 110 Days and 10.4 Hours
Revised: August 5, 2025
Accepted: August 21, 2025
Published online: October 27, 2025
Processing time: 110 Days and 10.4 Hours
Core Tip
Core Tip: In this study, we demonstrate that ANXA13 is up-regulated in hepatocellular carcinoma (HCC) and postulate that it contributes to tumor progression via post-transcriptional mechanisms. Correlation analyses indicate that ANXA13 may serve as a potential biomarker for HCC, thereby providing a reference for clinical diagnosis and the development of novel thera