Value of serum pepsinogen ratio screening for early gastric cancer and precancerous lesions in Youcheng area

Table 1 General information of three groups of patients

Data	Benign lesions (n = 135)	Precancerous lesions (n = 123)	Early GC (n = 127)	χ2/F value	P value
Sex, n (%)				3.819	0.148
Male	75 (55.56)	81 (65.85)	70 (55.12)
Female	60 (44.44)	42 (34.15)	57 (44.88)
Age (years), mean ± SD	56.34 ± 8.07	55.11 ± 7.26	56.50 ± 8.80	1.668	0.190
Body mass index (kg/m2), mean ± SD	23.03 ± 3.36	23.28 ± 3.07	22.67 ± 3.36	1.102	0.333
Family history of GC, n (%)				0.601	0.741
Without	127 (94.07)	116 (94.31)	117 (92.13)
With	8 (5.93)	7 (5.69)	10 (7.87)
History of smoking, n (%)				2.458	0.293
Without	81 (60.00)	62 (50.41)	72 (56.69)
With	54 (40.00)	61 (49.59)	55 (43.31)
History of drinking, n (%)				2.440	0.295
Without	101 (74.81)	85 (69.11)	84 (66.14)
With	34 (25.19)	38 (30.89)	43 (33.86)

GC: Gastric cancer.

Table 2 The value of pepsinogen ratio screening for precancerous lesions

Indicators	AUC	SE	95%CI	Cut-off value	Specificity (%)	Sensitivity (%)
PGR	0.611	0.035	0.542-0.680	34.17	38.52	96.75
H. pylori	0.582	0.036	0.512-0.652	/	57.04	59.35
Combined detection	0.689	0.034	0.623-0.754	0.50	71.85	66.67

PGR: Pepsinogen ratio; AUC: Area under the curve; H. pylori: Helicobacter pylori; CI: Confidence interval.

Table 3 Value of pepsinogen ratio screening for early gastric cancer

Screening indicator	Indicators	AUC	SE	95%CI	Cut-off value	Specificity (%)	Sensitivity (%)
Precancerous lesions and early GC	PGR	0.618	0.036	0.547-0.690	20.48	36.59	99.21
	H. pylori	0.502	0.037	0.430-0.573	/	59.35	40.94
	Combined detection	0.618	0.036	0.547-0.689	0.39	98.43	36.59
Benign lesions and early GC	PGR	0.708	0.032	0.644-0.771	20.68	50.37	99.21
	H. pylori	0.581	0.035	0.511-0.650	/	57.04	59.06
	Combined detection	0.750	0.030	0.690-0.809	0.38	44.44	99.21

GC: Gastric cancer; PGR: Pepsinogen ratio; AUC: Area under the curve; H. pylori: Helicobacter pylori; CI: Confidence interval.