Han X, Yu W. Value of serum pepsinogen ratio screening for early gastric cancer and precancerous lesions in Youcheng area. World J Gastrointest Surg 2024; 16(12): 3729-3736 [DOI: 10.4240/wjgs.v16.i12.3729]
Corresponding Author of This Article
Wei Yu, Health Management Center, Shengli Oilfield Central Hospital, No. 31 Jinan Road, Dongying District, Dongying 257000, Shandong Province, China. 13371542609@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Dec 27, 2024; 16(12): 3729-3736 Published online Dec 27, 2024. doi: 10.4240/wjgs.v16.i12.3729
Value of serum pepsinogen ratio screening for early gastric cancer and precancerous lesions in Youcheng area
Xue Han, Wei Yu
Xue Han, Department of General Practice, Shengli Oilfield Central Hospital, Dongying 257000, Shandong Province, China
Wei Yu, Health Management Center, Shengli Oilfield Central Hospital, Dongying 257000, Shandong Province, China
Author contributions: Han X designed the study, collected and analyzed data, and wrote the manuscript; Han X and Yu W participated in the conception of the study, data collection, design, and provided guidance; and all authors read and approved the final version.
Institutional review board statement: This study was approved by the Ethic Committee of Shengli Oilfield Central Hospital, approval No. 202403.
Informed consent statement: The requirement for written informed consent was not needed due to retrospective design of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Yu, Health Management Center, Shengli Oilfield Central Hospital, No. 31 Jinan Road, Dongying District, Dongying 257000, Shandong Province, China. 13371542609@163.com
Received: August 28, 2024 Revised: October 16, 2024 Accepted: October 28, 2024 Published online: December 27, 2024 Processing time: 91 Days and 1.6 Hours
Core Tip
Core Tip: To improve the 5-year survival rate of patients with gastric cancer and the detection rate of early gastric cancer (EGC), this study gathered the screening of patients with EGC and precancerous lesion (PCL) as a breakthrough for relevant research. We included 385 patients with gastric lesions in the Youcheng area for clinical analysis and revealed that pepsinogen ratio has the highest diagnostic efficiency in differentiating patients with benign lesions from those with EGC, followed by differentiating patients with PCL from those with EGC and finally distinguishing patients with benign lesions from those with PCL. The combined pepsinogen ratio and Helicobacter pylori detection exhibited a significant efficacy improvement effect in distinguishing patients with benign lesions from those with PCL, as well as differentiating patients with benign lesions from those with EGC.
