Predictive value of systemic immune-inflammation index and serum lactoferrin for postoperative survival in older patients with colon cancer

Figure 1 Detection of serum lactoferrin. ^aP < 0.05 vs pre-op 3 days; ^bP < 0.05 vs post-op 1 week; ^cP < 0.05 vs post-op 3 months.

Figure 2  Survival curve analysis results.

Figure 3 Area under the curve area under the curve of the predictive value of systemic immune-inflammation index, lactoferrin level, and other indicators for overall survival and disease-free survival. CRP: C-reactive protein; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9.

Figure 4 Prognostic factors for postoperative survival in older patients with colon cancer. A: Forest plot of multivariate Cox regression analysis showing systemic immune-inflammation index systemic immune-inflammation (SII) > 650, lactoferrin (> 200 ng/mL), and carcinoembryonic antigen (carcinoembryonic antigen > 5.0 ng/mL) as independent predictors of postoperative outcomes; B: Forest plot of multivariate Cox regression analysis showing traditional tumor, node, metastasis stage III, lactoferrin (> 200 ng/mL), and systemic immune-inflammation index (SII > 650) as independent prognostic factors for postoperative survival. SII: Systemic immune-inflammation; CEA: Carcinoembryonic antigen; TNM: Traditional tumor, node, metastasis.