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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Nov 27, 2025; 17(11): 110879
Published online Nov 27, 2025. doi: 10.4240/wjgs.v17.i11.110879
Published online Nov 27, 2025. doi: 10.4240/wjgs.v17.i11.110879
Predictive value of systemic immune-inflammation index and serum lactoferrin for postoperative survival in older patients with colon cancer
Sha-Sha Zhu, Tao Yang, Li-Li Cheng, Department of Laboratory, Rugao People's Hospital, Rugao 226500, Jiangsu Province, China
Co-first authors: Sha-Sha Zhu and Tao Yang.
Author contributions: Zhu SS and Yang T conceived the project; Cheng LL collected and analyzed the data; Zhu SS and Yang T jointly wrote the initial draft of the manuscript; Cheng LL provided expert advice and revised the manuscript. All the authors contributed to the study and approved the submitted version. Zhu SS and Yang T contributed equally to this work as co-first authors.
Supported by Rugao Science and Technology Research and Development Program (Agriculture and Social Development) Project, No. SRGS (24)061.
Institutional review board statement: This study has been reviewed and approved by the Ethics Committee of Rugao People's Hospital.
Clinical trial registration statement: This study is registered in https://www.researchregistry.com. The registration identification number is [Researchregistry11471].
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: We declare that there is no conflict of interest.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Data sharing statement: No data available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Li Cheng, MBBS, Department of Laboratory, Rugao People's Hospital, No. 278 Ninghai Road, Rugao 226500, Jiangsu Province, China.
Received: July 22, 2025
Revised: August 21, 2025
Accepted: September 15, 2025
Published online: November 27, 2025
Processing time: 125 Days and 19.7 Hours
Revised: August 21, 2025
Accepted: September 15, 2025
Published online: November 27, 2025
Processing time: 125 Days and 19.7 Hours
Core Tip
Core Tip: This study prospectively evaluated the predictive value of systemic immune-inflammation index (SII) combined with serum lactoferrin (LF) levels for survival outcomes in older patients with colon cancer undergoing radical surgery. Dynamic monitoring demonstrated that preoperative SII and LF levels were independent predictors of overall survival and disease-free survival. The findings suggest that SII and LF serve as simple and effective prognostic biomarkers, providing valuable guidance for individualized treatment strategies and postoperative recurrence risk assessment in elderly colon cancer patients.