New rabbit model for benign biliary stricture formation with repeatable administration

Figure 1 Establishment of a rabbit model of benign biliary stricture. A: Identification of the common bile duct; B: Injury to the common bile duct; C: Ligation of the cystic duct; D: Cholecystectomy; E: Placement of a drainage tube; F: Percutaneous back fixation.

Figure 2 Serological results of the two groups detected using a biochemical analyzer. A: Total bilirubin content; B: Conjugated bilirubin content; C: Alkaline phosphatase content; D: Alanine aminotransferase content; E: γ-glutamyl transferase content. ^aP < 0.0001; ^bP < 0.005. TBIL: Total bilirubin; DBIL: Direct bilirubin; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; GGT: γ-glutamyl transferase.

Figure 3 Angiographic evaluation of the biliary drainage tube. A: No contrast medium was infused; B: Contrast medium was injected through the drainage tube for visualization. a: Right hepatic duct; b: Left hepatic duct; c: Ductuli hepaticus communis; d: Common bile duct; e: Gallbladder stump; f: Cystic duct; g: Lower common bile duct stenosis.

Figure 4 Morphological changes of the bile duct. A: Healthy control group; B: Model group.

Figure 5 Hematoxylin and eosin staining of bile duct and liver tissues in the two groups (magnification, 4 ×). A: Healthy control group; B: Model group.

Figure 6 Masson staining of bile duct and liver tissues in the two groups (magnification, 2 ×). A: Healthy control group; B: Model group.