New rabbit model for benign biliary stricture formation with repeatable administration

doi:10.4240/wjgs.v16.i11.3538

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Nov 27, 2024 (publication date) through Nov 4, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastrointest Surg. Nov 27, 2024; 16(11): 3538-3545
Published online Nov 27, 2024. doi: 10.4240/wjgs.v16.i11.3538

New rabbit model for benign biliary stricture formation with repeatable administration

Qiu-Yue Sun, Yi-Ming Cheng, Yu-Hui Sun, Jin Huang

Qiu-Yue Sun, Yi-Ming Cheng, Yu-Hui Sun, Jin Huang, Department of Gastroenterology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213161, Jiangsu Province, China

Qiu-Yue Sun, Yu-Hui Sun, Department of Gastroenterology, Graduate School of Nanjing Medical University, Nanjing 211166, Jiangsu Province, China

Author contributions: Sun QY wrote the paper, performed the experiments, and acquired the data; Cheng YM analyzed and interpreted the data; Sun YH contributed to the linguistic formatting and correction of the manuscript; Huang J designed the research; all authors have read and approved the final manuscript.

Supported by The Key Project of Changzhou Medical Center of Nanjing Medical University, No. CMCM202310 and No. CMCC202209; and Science and Technology Development Fund of Nanjing Medical University, No. NMUB20220196.

Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Ethics Committee of Changzhou University.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: The data are available from the corresponding author at hj042153@hotmail.com.

ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Jin Huang, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, No. 68 Gehu Road, Wujin District, Changzhou 213161, Jiangsu Province, China. hj042153@hotmail.com

Received: June 19, 2024
Revised: August 29, 2024
Accepted: September 10, 2024
Published online: November 27, 2024
Processing time: 132 Days and 21 Hours

Core Tip

Core Tip: A model of benign biliary stricture (BBS) was established and certified by biliary drainage angiography, pathology, and other evaluations. This model could allow better long-term low-dose repeated action of drugs on biliary scars, and provide new ideas for the treatment of BBS. When the efficacy of this model is confirmed, new biological agents can be used to treat BBS in humans through endoscopic retrograde cholangiopancreatography in the future.