Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. May 27, 2026; 18(5): 118355
Published online May 27, 2026. doi: 10.4240/wjgs.v18.i5.118355
Published online May 27, 2026. doi: 10.4240/wjgs.v18.i5.118355
Evolving therapeutic landscape of duodenal neuroendocrine neoplasms: From endoscopic resection to systemic strategies
Song Fei, Peng Wei, Nie Ming, Hai-Bo Yao, Department of Gastrointestinal Surgery, Zhejiang Provincial People’s Hospital Bijie Hospital (The First People’s Hospital of Bijie), Bijie 551700, Guizhou Province, China
Author contributions: Fei S drafted the majority of the manuscript; Peng W and Ming M searched the literature of the neuroendocrine tumor of the duodenum; Yao HB revised and approved the manuscript; and all authors read and approved the final manuscript.
AI contribution statement: The DeepSeek AI tool was used for language polishing, translation, and writing assistance of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Hai-Bo Yao, PhD, Professor, Department of Gastrointestinal Surgery, Zhejiang Provincial People’s Hospital Bijie Hospital (The First People’s Hospital of Bijie), No. 112 Guanghui Road, Bijie 551700, Guizhou Province, China. yhb0129@126.com
Received: December 30, 2025
Revised: February 10, 2026
Accepted: March 17, 2026
Published online: May 27, 2026
Processing time: 148 Days and 22 Hours
Revised: February 10, 2026
Accepted: March 17, 2026
Published online: May 27, 2026
Processing time: 148 Days and 22 Hours
Core Tip
Core Tip: Neuroendocrine tumors (NETs) arise from the body’s diffuse endocrine system. Duodenal NETs represent a heterogeneous and uncommon neoplasm, frequently diagnosed serendipitously during clinical evaluation. Significant conceptual ambiguity persists regarding their clinicopathological manifestations, diagnostic algorithms, and therapeutic paradigms. This review provides a lucid and structured synthesis of contemporary evidence, delineating current understanding and critical knowledge gaps in duodenal NETs’ pathophysiology and management.