Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Apr 27, 2026; 18(4): 119293
Published online Apr 27, 2026. doi: 10.4240/wjgs.v18.i4.119293
Published online Apr 27, 2026. doi: 10.4240/wjgs.v18.i4.119293
Impact of oxiracetam on postoperative delirium in elderly patients undergoing laparoscopic gastrointestinal surgery
Bao-Sheng Lv, Yan Ma, Jia-Lu Wang, Hui Gao, Department of Anesthesiology, Hebei Yanda Hospital, Langfang 065201, Hebei Province, China
Wei Wang, Department of Neurology, Hebei Yanda Hospital, Langfang 065201, Hebei Province, China
Mu Jin, Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China
Author contributions: Lv BS and Wang W concepted and designed the study; Jin M, Ma Y, Wang JL and Gao H collected and analyzed the data; Lv BS wrote the manuscript. All authors have read and approved the final manuscript.
Supported by Natural Science Foundation of Hebei Province, No. H2021103001.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Hebei Yanda Hospital, No. 2021-3-008.
Clinical trial registration statement: The study protocol was registered in the Chinese Clinical Trial Registry, No. ChiCTR2300076112.
Informed consent statement: Written informed consent was obtained from all patients or their legal guardians.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Corresponding author: Wei Wang, MD, Department of Neurology, Hebei Yanda Hospital, Yanjiao Development Zone, Langfang 065201, Hebei Province, China.
Received: January 27, 2026
Revised: February 12, 2026
Accepted: March 10, 2026
Published online: April 27, 2026
Processing time: 88 Days and 1 Hours
Revised: February 12, 2026
Accepted: March 10, 2026
Published online: April 27, 2026
Processing time: 88 Days and 1 Hours
Core Tip
Core Tip: Perioperative intravenous oxiracetam safely and effectively reduces the risk of postoperative delirium in elderly patients undergoing laparoscopic gastrointestinal surgery, and maintains postoperative cognitive functionality. Its protective effect likely involves multi-target mechanisms, including stabilization complex modulation of the systemic immune response, rather than dependence on simple suppression of a single inflammatory pathway. This study provides a foundation for the clinical application of oxiracetam as a perioperative brain protection strategy for elderly surgical patients.