Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Apr 27, 2026; 18(4): 115954
Published online Apr 27, 2026. doi: 10.4240/wjgs.v18.i4.115954
Published online Apr 27, 2026. doi: 10.4240/wjgs.v18.i4.115954
Giant serosal cavernous hemangioma of the ileum: A case report and review of literature
Hai-Bo Si, Department of Colorectal and Anal Surgery, Chaoyang Central Hospital, Chaoyang 122000, Liaoning Province, China
Hao-Jie Qin, Fang-Fang Nie, First Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning Province, China
Yong-Peng Wang, Fang-Fang Nie, Department of Gastroenterology, Cancer Hospital of Dalian University of Technology/Liaoning Cancer Hospital and Institute/Cancer Hospital of China Medical University, Shenyang 110042, Liaoning Province, China
Co-first authors: Hai-Bo Si and Hao-Jie Qin.
Author contributions: Si HB and Qin HJ contributed equally to this manuscript and are co-first authors. Si HB provides consultation in gastrointestinal surgery and manuscript editing; Qin HJ is responsible for clinical management and manuscript writing; Nie FF is responsible for postoperative gastrointestinal management and tracking patient prognosis; Wang YP is responsible for surgery and manuscript revision.
Supported by Beijing Science and Technology Innovation Medical Development Foundation, No. KC2021-JX-0186-139; Chinese Anti-Cancer Society-Hengrui PARP-Inhibitor Oncology Research Fund.
Informed consent statement: Informed consent has been obtained from the patient.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Yong-Peng Wang, Department of Gastroenterology, Cancer Hospital of Dalian University of Technology/Liaoning Cancer Hospital and Institute/Cancer Hospital of China Medical University, No. 44 Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China. wangyongpeng@cancerhosp-ln-cmu.com
Received: October 31, 2025
Revised: December 18, 2025
Accepted: February 3, 2026
Published online: April 27, 2026
Processing time: 176 Days and 22.9 Hours
Revised: December 18, 2025
Accepted: February 3, 2026
Published online: April 27, 2026
Processing time: 176 Days and 22.9 Hours
Core Tip
Core Tip: This article reports a rare case of ileal serosal cavernous hemangioma. The lesion is fundamentally a vascular malformation rather than a true neoplasm, associated with aberrant activation of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway due to TEK/PIK3CA gene mutations. Although benign, its pseudo-infiltrative growth pattern and potential risk of delayed rupture can lead to severe complications. This case highlights that even asymptomatic lesions should be evaluated based on their long-term risks, and surgical resection remains the primary curative strategy. Enhanced clinical awareness is crucial for early diagnosis and intervention.