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World J Gastrointest Surg. Mar 27, 2026; 18(3): 117693
Published online Mar 27, 2026. doi: 10.4240/wjgs.v18.i3.117693
Published online Mar 27, 2026. doi: 10.4240/wjgs.v18.i3.117693
Crohn’s disease-related perianal fistula: A clinic research
Wei-Feng Zhang, Wei-Wei Gao, Zheng Wu, Ran-Ran Liu, Cheng-Wei Ruan, Department of Colorectal Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China
Wen-Ting Fan, Department of Clinical Laboratory, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China
Author contributions: Ruan CW served as the guarantor of integrity for the entire study; Zhang WF, Wu Z and Fan WT led the manuscript drafting; Zhang WF and Gao WW conducted the literature research; Zhang WF and Gao WW, and Liu RR performed statistical analysis; Zhang WF and Ruan CW completed manuscript editing. All authors have read, approved, and agreed to submit the final version of this manuscript, and ensure that any questions related to the work will be appropriately resolved. All authors contributed to study conception and design, data acquisition, analysis, and interpretation.
Supported by Construction Project of High Level Hospital of Jiangsu Province, No. GSPJS202508.
Institutional review board statement: This study was conducted in accordance with the Declaration of Helsinki and was reviewed and approved by the Institutional Review Board of The Affiliated Hospital of Xuzhou Medical University (approval No. XYFY2020-JS025-01).
Clinical trial registration statement: This study is registered at https://www.chictr.org.cn/showproj.html?proj = 193983 (No. ChiCTR2400091852).
Informed consent statement: Written informed consent was obtained from all individual participants and their family members included in the study. Patients were fully informed about the study’s purpose, procedures, potential risks, and benefits, and they participated voluntarily.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: All data generated or analyzed during this study are included in this article. Further inquiries can be directed to the corresponding author.
Corresponding author: Cheng-Wei Ruan, Researcher, Department of Colorectal Surgery, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Xuzhou 221004, Jiangsu Province, China. ruancw666@126.com
Received: December 26, 2025
Revised: January 19, 2026
Accepted: February 3, 2026
Published online: March 27, 2026
Processing time: 91 Days and 3.9 Hours
Revised: January 19, 2026
Accepted: February 3, 2026
Published online: March 27, 2026
Processing time: 91 Days and 3.9 Hours
Core Tip
Core Tip: This study is the first to evaluate the efficacy of the comprehensive regimen of seton drainage combined with oral and external Traditional Chinese medicine (TCM) for the treatment of simple Crohn’s disease-related perianal fistula. The results demonstrate that this regimen can significantly shorten wound healing time, improve TCM syndromes and perianal symptoms, and has a favorable safety profile, thereby providing a novel integrated TCM and Western medicine therapeutic strategy for clinical practice.