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World J Gastrointest Surg. Mar 27, 2026; 18(3): 115383
Published online Mar 27, 2026. doi: 10.4240/wjgs.v18.i3.115383
Published online Mar 27, 2026. doi: 10.4240/wjgs.v18.i3.115383
Impact of indomethacin combined with pancreatic duct stent placement on high-risk populations of pancreatitis after endoscopic retrograde cholangiopancreatography
Kai Xu, Dong-Hai Zhou, Jing-Shan Liu, Department of General Surgery, Peking University Shougang Hospital, Beijing 100041, China
Jian Feng, Department of Hepatopancreatobiliary Surgery, Peking University Shougang Hospital, Beijing 100144, China
Author contributions: Xu K was responsible for conceptualization, methodology, writing original draft, supervision, project administration, and funding acquisition; Zhou DH and Liu JS undertook formal analysis and investigation; Liu JS and Feng J handled investigation and resources; and all authors contributed to writing review and editing.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Peking University Shougang Hospital, approval No. IRBK-2025-015-02.
Clinical trial registration statement: It was not prospectively registered in a public clinical trials database.
Informed consent statement: The informed consent of the patient has been obtained.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The data that support the findings of this study are available from the corresponding author Kai Xu, upon reasonable request. The data are not publicly available due to privacy or ethical restrictions. To gain access, requestors will need to sign a data access agreement.
Corresponding author: Kai Xu, MD, PhD, Department of General Surgery, Peking University Shougang Hospital, No. 9 Jinyuangzhuang Road, Beijing 100041, China.
Received: October 24, 2025
Revised: November 28, 2025
Accepted: January 12, 2026
Published online: March 27, 2026
Processing time: 154 Days and 5.3 Hours
Revised: November 28, 2025
Accepted: January 12, 2026
Published online: March 27, 2026
Processing time: 154 Days and 5.3 Hours
Core Tip
Core Tip: This study demonstrates that combining indomethacin suppositories with pancreatic duct stent placement significantly reduces postoperative inflammatory markers (interleukin-6, interleukin-10, C-reactive protein) and improves immune function (higher CD4+/CD8+ ratio) in high-risk post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) patients. The dual intervention also shortens pain relief time and hospital stays compared to monotherapy, offering a synergistic strategy to mitigate PEP-related complications. Key findings highlight its superiority in modulating inflammation and enhancing recovery without increasing severe PEP incidence.