©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Feb 27, 2026; 18(2): 114607
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.114607
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.114607
Impact of nutritional status on treatment completion and prognosis during adjuvant chemotherapy following gastric cancer surgery
Ke Zhou, Ren-Feng Tu, Li-Huai Lu, Department of Hematology and Oncology, The People’s Hospital of Pingyang, Wenzhou 325400, Zhejiang Province, China
Hong Zhang, Department of Renal Rheumatology and Immunology, The People’s Hospital of Pingyang, Wenzhou 325400, Zhejiang Province, China
Author contributions: Zhou K designed research and wrote the paper; Zhang H performed research; Lu LH contributed new reagents or analytic tools; Tu RF analyzed data.
Institutional review board statement: The study protocol was approved by the Institutional Review Board of Pingyang County People’s Hospital, No. LW-2025-050.
Informed consent statement: Due to the retrospective nature of this study, the requirement for signed informed consent was waived.
Conflict-of-interest statement: The authors declared that they had no conflicts of interest relevant to this study.
Data sharing statement: No additional data are available.
Corresponding author: Hong Zhang, Department of Renal Rheumatology and Immunology, The People’s Hospital of Pingyang, No. 555 Kun’ao Avenue, Wenzhou 325400, Zhejiang Province, China. xiao_rikui2@163.com
Received: October 28, 2025
Revised: December 4, 2025
Accepted: December 24, 2025
Published online: February 27, 2026
Processing time: 120 Days and 22.3 Hours
Revised: December 4, 2025
Accepted: December 24, 2025
Published online: February 27, 2026
Processing time: 120 Days and 22.3 Hours
Core Tip
Core Tip: This study investigated the impact of nutritional status on treatment completion and prognosis in gastric cancer patients undergoing adjuvant chemotherapy after surgery. Nutritional Risk Screening 2002 ≥ 3 was identified as an independent risk factor for reduced chemotherapy completion and poor survival. Patients with nutritional risk experienced more severe toxicities, lower relative dose intensity, and worse 3-year disease-free and overall survival. Routine nutritional risk assessment and timely intervention may improve chemotherapy adherence and outcomes in gastric cancer patients.