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World J Gastrointest Surg. Feb 27, 2026; 18(2): 112169
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.112169
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.112169
Serum inflammatory biomarkers can predict clinical outcomes in patients with sepsis-associated gastrointestinal dysfunction
You-Hui Liu, Qing-Yang Chen, Fei-Yue Dai, Department of Intensive Care Unit, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China
Xin-Yu Chen, Department of Internal Medicine, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China
Author contributions: Liu YH wrote the manuscript; Liu YH and Chen XY reviewed the manuscript; Liu YH, Chen QY, Dai FY, and Chen XY collected the data; all authors annotated the manuscript.
Supported by National Chinese Medicine Advantage Specialty Construction Project, No. Czxm-zzyxk-2024001.
Institutional review board statement: This study was approved by the Ethic Committee of The First Hospital of Hunan University of Chinese Medicine, No. HN-LL-KY-2025-052-01.
Informed consent statement: Patients were not required to give informed consent for this study, as it is a retrospective clinical study and the analysis used previous clinical data.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Xin-Yu Chen, MD, Department of Internal Medicine, The First Hospital of Hunan University of Chinese Medicine, No. 95 Shaoshan Middle Road, Yuhua District, Changsha 410007, Hunan Province, China. chenxinyuchen1@163.com
Received: September 9, 2025
Revised: October 30, 2025
Accepted: December 16, 2025
Published online: February 27, 2026
Processing time: 169 Days and 22.7 Hours
Revised: October 30, 2025
Accepted: December 16, 2025
Published online: February 27, 2026
Processing time: 169 Days and 22.7 Hours
Core Tip
Core Tip: This study analyzed 117 patients with sepsis-associated gastrointestinal dysfunction and identified procalcitonin, C-reactive protein, tumor necrosis factor-alpha, and interleukin-6/10 as key biomarkers of disease severity and prognosis. Elevated C-reactive protein and tumor necrosis factor-alpha levels and higher Sequential Organ Failure Assessment scores increased the likelihood of poor outcomes, while combining multiple biomarkers significantly improved predictive accuracy.