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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jan 27, 2026; 18(1): 114309
Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.114309
Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.114309
Timeliness of postoperative serum carcinoembryonic antigen monitoring for predicting recurrence after gastric cancer surgery
Xin-Xing Duan, Xiong Yu, Li Zhou, General Surgery Center, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No. 1 People's Hospital, Jiujiang 332000, Jiangxi Province, China
Author contributions: Duan XX designed the study, collected and analyzed the data, and drafted the initial manuscript; Yu X participated in data verification and provided critical input during manuscript refinement; Zhou L supervised the entire research process, formulated key research directions, revised the manuscript for intellectual content, coordinated peer review responses, and ensured the integrity of the work; all authors have read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No. 1 People's Hospital (Approval No. JJSDYRMYY-YXLL-2024-239).
Informed consent statement: All participants provided written informed consent before enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li Zhou, MBBS, Chief Nurse, General Surgery Center, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No. 1 People's Hospital, No. 48 Taling South Road, Xunyang District, Jiujiang 332000, Jiangxi Province, China. liwei880904oioi@163.com
Received: September 16, 2025
Revised: October 22, 2025
Accepted: November 19, 2025
Published online: January 27, 2026
Processing time: 127 Days and 19.2 Hours
Revised: October 22, 2025
Accepted: November 19, 2025
Published online: January 27, 2026
Processing time: 127 Days and 19.2 Hours
Core Tip
Core Tip: Dynamic monitoring of carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP) levels at three and six months after gastrectomy is crucial for postoperative management of gastric cancer. Elevated levels of these markers serve as independent risk factors for recurrence. Combined assessment of CEA and AFP enhances predictive accuracy, yielding an area under the curve of 0.826, and offers superior sensitivity and specificity compared with either marker alone. This combined approach facilitates earlier detection and timely intervention for recurrent gastric cancer.