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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jan 27, 2026; 18(1): 114227
Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.114227
Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.114227
Admission hyperphosphatemia as a predictor of severity and mortality in acute pancreatitis: A 1000-patient cohort study
Yavuz Özden, Nuh Mehmet Buyukberber, Department of Gastroenterology, Kayseri City Hospital, University of Health Sciences, Kayseri 38080, Türkiye
Author contributions: Özden Y contributed to conceptualization, data acquisition, data analysis and interpretation, manuscript drafting, critical revision of the manuscript, and overall supervision; Buyukberber NM contributed to methodology, validation, data interpretation, and critical review of the final manuscript. All authors have read and approved the final version of the manuscript and agreed to be accountable for all aspects of the work.
Institutional review board statement: The study protocol was approved by the Ethics Committee of the University of Health Sciences, Kayseri City Hospital (Approval No: 2025/288) and complied with the principles of the Declaration of Helsinki.
Informed consent statement: The requirement for informed consent was waived due to the retrospective nature of the study. All patient data were anonymized prior to analysis.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest related to this study.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The data supporting the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yavuz Özden, MD, Department of Gastroenterology, Kayseri City Hospital, University of Health Sciences, Şeker District, Muhsin Yazıcıoğlu Boulevard No. 77 Kocasinan, Kayseri 38080, Türkiye. yavuzozden@gmail.com
Received: September 16, 2025
Revised: October 22, 2025
Accepted: November 27, 2025
Published online: January 27, 2026
Processing time: 129 Days and 12.4 Hours
Revised: October 22, 2025
Accepted: November 27, 2025
Published online: January 27, 2026
Processing time: 129 Days and 12.4 Hours
Core Tip
Core Tip: Early risk stratification in acute pancreatitis remains a major clinical challenge, as conventional scoring systems require up to 48 hours and limit decision-making in the emergency setting. In this large 1000-patient cohort, admission hyperphosphatemia was strongly associated with severe disease, pancreatic necrosis, intensive care requirement, and 30-day mortality and was identified as an independent predictor of poor outcomes. These findings suggest that serum phosphate is an inexpensive, readily available biomarker that may complement existing tools and enable the prompt identification of high-risk patients at hospital admission.