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Retrospective Study
Copyright ©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jan 27, 2026; 18(1): 114164
Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.114164
Analysis of quality of life and reflux oesophagitis following Billroth II and Roux-en-Y gastrointestinal reconstruction for gastric cancer
Xin-Xing Duan, Xiong Yu, Jin Gan
Xin-Xing Duan, Xiong Yu, Jin Gan, General Surgery Center, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No. 1 People's Hospital, Jiujiang 332000, Jiangxi Province, China
Author contributions: Duan XX designed the study, conducted data collection and analysis, and drafted the initial manuscript; Yu X participated in data verification and provided critical input on manuscript content refinement; Gan J supervised the entire research process, formulated key research directions, revised the manuscript for intellectual content, coordinated peer review responses, and ensured the integrity of the work. All authors have read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No. 1 People's Hospital.
Informed consent statement: All the individuals who participated in this study provided their written informed consent prior to study enrolment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin Gan, MD, General Surgery Center, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No. 1 People's Hospital, No. 48 Taling South Road, Xunyang District, Jiujiang 332000, Jiangxi Province, China. gj19863419@163.com
Received: September 15, 2025
Revised: October 9, 2025
Accepted: November 18, 2025
Published online: January 27, 2026
Processing time: 131 Days and 0.8 Hours
Core Tip

Core Tip: This study demonstrates that compared to Billroth II reconstruction, Roux-en-Y anastomosis significantly reduces the incidence of gastroesophageal reflux and reflux esophagitis, alleviates reflux-related symptoms, and improves postoperative quality of life (QoL) in gastric cancer patients after radical distal gastrectomy. Although operative time may be longer with Roux-en-Y, it offers superior long-term functional outcomes by minimizing bile reflux and associated complications, without compromising nutritional status. Roux-en-Y reconstruction is recommended for its enhanced QoL benefits and reduced reflux morbidity.