Copyright
©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jan 27, 2026; 18(1): 113350
Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.113350
Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.113350
Clinical characteristics of and risk factors for hepatolithiasis developed after surgery for congenital biliary dilatation
Fumio Asano, Ryusei Matsuyama, Takafumi Kumamoto, Daisuke Morioka, Itaru Endo, Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Kanagawa, Japan
Masato Shinkai, Department of Surgery, Kanagawa Children’s Medical Center, Yokohama 232-8555, Kanagawa, Japan
Satoru Shinoda, Department of Biostatistics, Yokohama City University School of Medicine, Yokohama 236-0004, Kanagawa, Japan
Author contributions: Asano F, Matsuyama R, and Morioka D wrote the manuscript; Asano F, Matsuyama R and Endo I participated in the conception and design of the study; Asano F, Kumamoto T, and Shinkai M were involved in data acquisition; Asano F and Shinoda S were involved in the statistical analysis of the data; all the authors participated in the interpretation of the data, and all the authors were responsible for the decision to submit the manuscript for publication.
Institutional review board statement: This investigation was approved by Institutional Ethics Committee of Yokohama City University, No. F241000006 (same in the two university hospitals) and Institutional Ethics Committee of Kanagawa Children’s Medical Center, No. C119-2024-92.
Informed consent statement: The need for patient consent was waived because of the retrospective nature of the study.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fumio Asano, MD, Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa Ward, Yokohama 236-0004, Kanagawa, Japan. t136001f@yokohama-cu.ac.jp
Received: August 29, 2025
Revised: September 17, 2025
Accepted: November 10, 2025
Published online: January 27, 2026
Processing time: 145 Days and 10.2 Hours
Revised: September 17, 2025
Accepted: November 10, 2025
Published online: January 27, 2026
Processing time: 145 Days and 10.2 Hours
Core Tip
Core Tip: A total of 223 patients with congenital biliary dilatation (CBD) who underwent extrahepatic bile duct resection were retrospectively examined to clarify the clinical impact of hepatolithiasis (HL) that developed after CBD surgery. Among these 223 patients, 15 (6.7%) developed HL. Among these 15 patients, 2 developed biliary cirrhosis: (1) One died of liver failure; and (2) The other required liver transplantation. Two additional patients required major hepatectomy. Most of the remaining 11 patients underwent repeated hospitalization for lithotomy. Statistical analysis revealed that older age at the time of CBD surgery was an independent risk factor for the development of HL.