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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jan 27, 2026; 18(1): 112767
Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.112767
Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.112767
Predictors of mortality and liver transplant requirement in patients with hepatitis A virus: A case series from Mexico
Cristian Alejandro Bautista-Mondragón, Pablo Mondragón-Ratkovich, Department of Internal Medicine, Medica Sur Clinic, Mexico City 14050, Ciudad de México, Mexico
Alejandra Madeleine Mijangos-Trejo, Norberto Carlos Chávez-Tapia, Gastroenterology and Obesity Unit, Medica Sur Clinic, Mexico City 14050, Ciudad de México, Mexico
Octavio González-Chon, Medica Sur Clinic, Mexico City 14050, Ciudad de México, Mexico
Author contributions: Bautista-Mondragón CA and Mondragón-Ratkovich P contributed to the data collection, processing, and analysis; Mijangos-Trejo AM and Chávez-Tapia NC validated and reviewed the information used in the theoretical framework; Mijangos-Trejo AM, González-Chon O, and Chávez-Tapia NC supervised database creation and analysis; Bautista-Mondragón CA conducted the literature review, protocol development, and prepared the final report for dissemination; Chávez-Tapia NC ensured the reliability of laboratory results and prognostic scales; González-Chon O validated and reviewed the theoretical framework, and provided statistical guidance.
Institutional review board statement: This study was reviewed and approved by the Research Ethics Committee of Medica Sur Clinic (CONBIOETICA-09-CEI-018-20160729). The study was conducted in accordance with the Declaration of Helsinki and institutional guidelines.
Informed consent statement: Because of the retrospective design, the requirement for informed consent was waived by the Research Ethics Committee. All patient data were anonymized and handled with strict confidentiality.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets generated and/or analyzed during the current study are not publicly available due to institutional data protection policies but are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Norberto Carlos Chávez-Tapia, MD, Gastroenterology and Obesity Unit, Medica Sur Clinic, Puente de Piedra No. 150, Mexico City 14050, Ciudad de México, Mexico. n.chaveztapia@pm.me
Received: August 6, 2025
Revised: September 23, 2025
Accepted: November 10, 2025
Published online: January 27, 2026
Processing time: 169 Days and 6.2 Hours
Revised: September 23, 2025
Accepted: November 10, 2025
Published online: January 27, 2026
Processing time: 169 Days and 6.2 Hours
Core Tip
Core Tip: Hepatitis A virus infection is among the most common causes of acute viral hepatitis globally. Predicting the clinical course of hepatitis A virus infection remains challenging. Risk factors such as encephalopathy, leukocytosis, acute kidney injury, hypoalbuminemia, and hyperbilirubinemia can be used to identify patients at risk for developing acute liver failure. Previously, we reported a fulminant hepatitis incidence of 0.3%, which increased to 1.8% in individuals older than 49 years, with serum creatinine level > 2 mg/dL being the strongest predictor of fulminant hepatitis or mortality. Given the epidemiological transition of this disease in Mexico, updated data are crucial.