Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2025; 17(9): 110125
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.110125
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.110125
Evaluation of pathological findings in predicting postoperative endoscopic recurrence in Crohn’s disease: A retrospective cohort study
Işıl Karabulut, Department of Surgery, Ankara Bilkent City Hospital, Ankara 06800, Türkiye
Erdinç Çetinkaya, Department of General Surgery, University of Health Sciences, Ankara Bilkent City Hospitale
Erdinç Çetinkaya, Department of Medical and Surgical Research, Institute of Health Sciences, Hacettepe University, Ankara 06100, Turkey
Nesrin Turhan, Department of Pathology, University of Health Sciences, Ankara City Hospital, Ankara 06800, Türkiye
Oyku Tayfur Yurekli, Department of Gastroenterology, School of Medicine, Yıldırım Beyazıt University, Ankara 06800, Türkiye
Mesut Tez, Department of Surgery, University of Health Sciences, Ankara City Hospital, Ankara 06800, Türkiye
Author contributions: Karabulut I conceptualized the study, collected data, and drafted the manuscript; Çetinkaya E assisted in data collection, performed statistical analysis, and reviewed the manuscript; Turhan N conducted histopathological re-evaluation of resection specimens and contributed to the interpretation of pathological findings; Yurekli OT provided expertise in gastroenterology, contributed to data interpretation, and revised the manuscript for intellectual content; Tez M supervised the study, contributed to the study design, coordinated the multidisciplinary council, and finalized the manuscript as the corresponding author. All authors have read and approved the final version of the manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Ankara Bilkent City Hospital, No. TABED 2-24-219.
Informed consent statement: Written informed consent was obtained from all participants.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author, Mesut Tez, upon reasonable request. Access to the data will be subject to approval by the Ethics Committee of Ankara Bilkent City Hospital to ensure compliance with privacy regulations and institutional policies. De-identified data may be shared for research purposes, provided the request aligns with the study’s ethical approvals and data protection guidelines.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mesut Tez, MD, Department of Surgery, University of Health Sciences, Ankara City Hospital, No. 1 Bilkent Street, District of Universities, Ankara 06800, Türkiye.
Received: May 30, 2025
Revised: June 12, 2025
Accepted: July 17, 2025
Published online: September 27, 2025
Processing time: 117 Days and 19.6 Hours
Revised: June 12, 2025
Accepted: July 17, 2025
Published online: September 27, 2025
Processing time: 117 Days and 19.6 Hours
Core Tip
Core Tip: This study highlights the predictive role of histological findings in postoperative Crohn’s disease management. Specifically, neutrophilic cryptitis and crypt abscesses in resected specimens are significantly associated with endoscopic recurrence, as measured by the Rutgeerts score. These findings can guide clinicians in identifying high-risk Crohn’s disease patients for early intervention and intensified endoscopic monitoring to mitigate recurrence risks, with decisions supported by a weekly multidisciplinary council.