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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2025; 17(9): 108127
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.108127
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.108127
Effects of preoperative immunonutrition vs standard oral nutrition in patients undergoing colorectal surgery: A randomized controlled trial
Manivaasan Pannirselvam, Zaidi Zakaria, Michael Pak-Kai Wong, Andee Dzulkarnaen Zakaria, Muhammad Faeid Othman, Department of Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Mohd Hady Shukri Abdul Satar, Department of Surgery, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia
Nor Syarahani Jusoh, Department of Dietetic and Food Services, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Co-corresponding authors: Andee Dzulkarnaen Zakaria and Muhammad Faeid Othman.
Author contributions: Pannirselvam M, Zakaria AD, Othman MF, and Wong MPK designed the overall concept and outline of the manuscript; Zakaria AD, Othman MF, Zakaria Z, Abdul Satar MHS, and Jusoh NS contributed to the discussion and design of the manuscript; Pannirselvam M, Zakaria AD, Othman MF, Zakaria Z, and Abdul Satar MHS contributed to the writing, and editing the manuscript, illustrations, and review of literature; Zakaria AD and Othman MF contributed equally to this work as co-corresponding authors. All authors have read and approved the final manuscript.
Supported by Universiti Sains Malaysia, Short-Term Grant, No. R501-LR-RND002-0000000342-0000.
Institutional review board statement: This study was approved by the Jawatankuasa Etika Penyelidikan Manusia Universiti Sains Malaysia, No. USM/JEPeM/KK/23050402.
Clinical trial registration statement: This study is registered at www.clinicaltrials.gov. The registration identification number is NCT06128798.
Informed consent statement: All study participants or their legal guardian, provided informed consent prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The corresponding author will provide the data supporting this article upon request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Muhammad Faeid Othman, MD, Department of Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Jalan Raja Perempuan Zainab II, Kubang Kerian 16150, Kelantan, Malaysia. faeid@usm.my
Received: April 8, 2025
Revised: May 27, 2025
Accepted: July 31, 2025
Published online: September 27, 2025
Processing time: 171 Days and 7.9 Hours
Revised: May 27, 2025
Accepted: July 31, 2025
Published online: September 27, 2025
Processing time: 171 Days and 7.9 Hours
Core Tip
Core Tip: This randomized controlled trial evaluated the effects of preoperative immunonutrition vs standard oral nutrition supplements in patients undergoing colorectal surgery. Despite theoretical benefits, immunonutrition did not significantly improve postoperative gastrointestinal recovery, reduce infectious complications, or shorten hospital stay. All baseline and surgical variables were comparable between groups. The findings suggest that routine use of immunonutrition may not confer additional clinical advantages over standard supplementation in this patient population, challenging current recommendations and supporting a more individualized nutritional approach.