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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2025; 17(9): 107796
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.107796
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.107796
Role of vitamin D in the management of chronic pain after gastrointestinal surgery
Can-Can Cheng, Lang Yu, Ning Zheng, Fan Zhang, Qin Liao, Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China
Co-first authors: Can-Can Cheng and Lang Yu.
Co-corresponding authors: Fan Zhang and Qin Liao.
Author contributions: Cheng CC performed the majority of the writing, prepared the figures and tables; Yu L performed data accusation and writing; Zheng N provided the input in writing the paper; Zhang F and Liao Q designed the outline, coordinated the writing of the paper and answered reviewers.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qin Liao, MD, Doctor, Department of Anesthesiology, The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road, Changsha 410013, Hunan Province, China. xy3yyliaoqin@sina.com
Received: April 1, 2025
Revised: April 22, 2025
Accepted: July 14, 2025
Published online: September 27, 2025
Processing time: 179 Days and 20.2 Hours
Revised: April 22, 2025
Accepted: July 14, 2025
Published online: September 27, 2025
Processing time: 179 Days and 20.2 Hours
Core Tip
Core Tip: Vitamin D may play a beneficial role in managing chronic pain following gastrointestinal surgery and postoperative recovery by modulating immune responses, aiding neural repair, and regulating gastrointestinal function. While preliminary evidence is promising, further large-scale clinical trials are essential to confirm its effects in these patients.