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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2025; 17(9): 107301
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.107301
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.107301
Diagnostic significance of fluorine-18-fluorodeoxyglucose-positron emission tomography/computed tomography in differentiating Edmondson grade II and III hepatocellular carcinoma
Xiao-Bo Niu, Yan-Peng Li, Fang-Fang Chao, Xiao-Li Mei, Xing-Min Han, Rui-Hua Wang, Department of Nuclear Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Author contributions: Niu XB conceived, designed the study, and analyzed the data; Li YP and Chao FF guided the study; Niu XB, Mei XL, Han XM, and Wang RH collected the clinical date. All authors drafted and revised the manuscript.
Supported by National Natural Science Foundation of China, No. 82171983; and Henan Provincial Science and Technology Research Project, No. 242102311089.
Institutional review board statement: This study was approved by the Life Sciences Ethics Review Committee of Zhengzhou University.
Informed consent statement: The requirement for patients’ informed consent for this study was waived due to its retrospective nature.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rui-Hua Wang, DM, Department of Nuclear Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou 450052, Henan Province, China. wangruihua2004@126.com
Received: May 28, 2025
Revised: June 30, 2025
Accepted: August 6, 2025
Published online: September 27, 2025
Processing time: 119 Days and 0.8 Hours
Revised: June 30, 2025
Accepted: August 6, 2025
Published online: September 27, 2025
Processing time: 119 Days and 0.8 Hours
Core Tip
Core Tip: Fluorine-18-fluorodeoxyglucose (18F-FDG)-positron emission tomography/computed tomography technology has established its indispensable position in numerous aspects of liver cancer diagnosis, staging, lymph node metastasis assessment, and prognosis prediction. The hypermetabolic nature of malignant cells, induced by accelerated glycolysis, increases 18F-FDG uptake. Results have revealed an intimate connection between 18F-FDG uptake and hepatocellular carcinoma differentiation status. This study assessed the diagnostic potential of conventional and three-dimensional metabolic 18F-FDG-positron emission tomography/computed tomography parameters in differentiating Edmondson grade II from grade III hepatocellular carcinoma.