©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2025; 17(9): 101834
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.101834
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.101834
Role of endoscopic ultrasound-guided portal pressure gradient measurement in assessing liver function before liver-directed therapies
Ahmed Telbany, Department of Gastroenterology, University of New Mexico, Albuquerque, NM 87106, United States
Youssef Soliman, Toufic Kachaamy, Department of Gastroenterology, City of Hope, Phoenix, AZ 85338, United States
Gagandeep Singh, Department of Surgery, City of Hope, Phoenix, AZ 85338, United States
Khaled Abouelezz, Department of Oncology, City of Hope, Phoenix, AZ 85338, United States
Author contributions: Telbany A led the conceptualization, writing, and overall development of the manuscript; Kachaamy T led the conceptualization, writing, and overall development of the manuscript; Soliman Y, Singh G, Abouelezz K contributed to the critical review, editing, and refinement of the content. All authors approved the final version of the manuscript.
Conflict-of-interest statement: Microtech, consultant and royalties Olympus, consultant Steris Endoscopy, consultant Medtronic, consultant Pentax, Consultant Grail speakers Bureau Cook Medical consultant Creomedical educational support Boston Scientific, educational support Exact Science food and beverage.
Corresponding author: Toufic Kachaamy, AGAF, FACG, FASGE, Department of Gastro
Received: September 28, 2024
Revised: April 3, 2025
Accepted: May 13, 2025
Published online: September 27, 2025
Processing time: 361 Days and 8.5 Hours
Revised: April 3, 2025
Accepted: May 13, 2025
Published online: September 27, 2025
Processing time: 361 Days and 8.5 Hours
Core Tip
Core Tip: Assessment of portal hypertension, hepatic steatosis and fibrosis provides valuable prognostic information prior to liver-directed therapies. Endoscopic ultrasound-guided portal pressure gradient is an exciting emerging technique that warrants further investigation as a potentially safer and more accessible alternative to trans-jugular hepatic venous pressure gradient measurement.