Yuan XC, Jia P, Tian T, Zhu J, Zhang XY. Endoscopic submucosal dissection for esophageal precancerous lesions and early esophageal carcinoma: Analysis of efficacy and serum tumor markers. World J Gastrointest Surg 2025; 17(4): 103700 [DOI: 10.4240/wjgs.v17.i4.103700]
Corresponding Author of This Article
Xiao-Chen Yuan, Department of Gastroenterology, The Affiliated Taizhou Second People’s Hospital of Yangzhou University, No. 27 Jiankang Road, Jiangyan District, Taizhou 225300, Jiangsu Province, China. 15261020588@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Apr 27, 2025; 17(4): 103700 Published online Apr 27, 2025. doi: 10.4240/wjgs.v17.i4.103700
Endoscopic submucosal dissection for esophageal precancerous lesions and early esophageal carcinoma: Analysis of efficacy and serum tumor markers
Xiao-Chen Yuan, Ping Jia, Tian Tian, Jun Zhu, Xiao-Yan Zhang
Xiao-Chen Yuan, Ping Jia, Jun Zhu, Xiao-Yan Zhang, Department of Gastroenterology, The Affiliated Taizhou Second People’s Hospital of Yangzhou University, Taizhou 225300, Jiangsu Province, China
Tian Tian, Department of Laboratory Medicine, The Affiliated Taizhou Second People’s Hospital of Yangzhou University, Taizhou 225300, Jiangsu Province, China
Author contributions: Yuan XC designed the research and wrote the first manuscript; Yuan XC, Jia P, Tian T, Zhu J and Zhang XY contributed to conceiving the research and analyzing data; Yuan XC conducted the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of The Affiliated Taizhou Second People’s Hospital of Yangzhou University.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: Dr. Yuan has nothing to disclose.
Data sharing statement:sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Chen Yuan, Department of Gastroenterology, The Affiliated Taizhou Second People’s Hospital of Yangzhou University, No. 27 Jiankang Road, Jiangyan District, Taizhou 225300, Jiangsu Province, China. 15261020588@163.com
Received: January 8, 2025 Revised: February 25, 2025 Accepted: March 5, 2025 Published online: April 27, 2025 Processing time: 79 Days and 23.3 Hours
Core Tip
Core Tip: Studies on the efficacy of endoscopic submucosal dissection (ESD) in treating esophageal precancerous lesions (EPLs) or early esophageal carcinoma (EEC), as well as its effects on serum tumor markers (STMs) and the 6-month postoperative recurrence rate, remains limited. This study included 120 patients with EPL or EEC and compared the clinical outcomes of ESD with thoracotomy. The results indicate that ESD provides significant clinical advantages for these patients, including larger dissection area, higher resection rate per unit time, reduced risk of complications, less intraoperative bleeding, shorter operative duration, and accelerated recovery. Moreover, ESD effectively suppresses abnormal STM levels, such as carcinoembryonic antigen, carbohydrate antigen 724, and tumor-specific growth factor. These results provide comprehensive and robust clinical evidence to support the use of ESD in EPL and EEC management.
