Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Mar 27, 2025; 17(3): 102174
Published online Mar 27, 2025. doi: 10.4240/wjgs.v17.i3.102174
Rare large sigmoid hamartomatous polyp in an elderly patient with atypical Peutz-Jeghers syndrome: A case report
Zhe-Sen Tian, Xiao-Peng Ma, Hong-Xun Ruan, Yang Yang, Ya-Lei Zhao
Zhe-Sen Tian, Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Xiao-Peng Ma, Hong-Xun Ruan, Ya-Lei Zhao, Department of Anus and Intestine Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Yang Yang, Department of Anus and Intestine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei Province, China
Co-first authors: Zhe-Sen Tian and Xiao-Peng Ma.
Author contributions: Zhao YL, Tian ZS and Ma XP designed and performed the research; Tian ZS and Ruan HX collected the clinical data; Ma XP and Yang Y wrote the manuscript; all authors finished the approval of the final version manuscript; The contributions of Tian ZS and Ma XP were equal and they were co-first authors.
Supported by Medical Science Research Program of Hebei Province, No. 20250060.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ya-Lei Zhao, MD, Professor, Department of Anus and Intestine Surgery, The Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang 050000, Hebei Province, China. doctor_zhaoyalei@163.com
Received: October 10, 2024
Revised: December 17, 2024
Accepted: January 9, 2025
Published online: March 27, 2025
Processing time: 136 Days and 11.8 Hours
Core Tip

Core Tip: Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant hereditary illness defined by the connection of intestinal polyposis, mucosal skin pigmentation, and cancer risk. Due to the older age, the clinical features of mucosal hyperpigmentation were atypia in this case study. Due to the location of the polyp in the sigmoid colon, the common intussusception symptoms of PJS cases in the past did not appear, and only hematochesis and abdominal pain related symptoms were observed. PJS mainly occurs in children and adolescents, often with multiple small intestinal polyps. Such an advanced age with a rare polyp location has not been reported.