Perioperative neurocognitive dysfunction and role of dexmedetomidine in radical colon cancer surgery in elderly patients

doi:10.4240/wjgs.v17.i3.100126

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 3

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (0)

All Articles published online

The chart showing PDF series, HTML series, Tables (1-1) series.

Item

Count

PDF

HTML

Tables (1-1)

Sum=0

Mar 27, 2025 (publication date) through Feb 24, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Surgery

ISSN

1948-9366

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Editorial

World J Gastrointest Surg. Mar 27, 2025; 17(3): 100126
Published online Mar 27, 2025. doi: 10.4240/wjgs.v17.i3.100126

Perioperative neurocognitive dysfunction and role of dexmedetomidine in radical colon cancer surgery in elderly patients

Chandra K Pandey, Abhishek Kumar

Chandra K Pandey, Department of Anaesthesiology, Medanta Hospital Lucknow, Lucknow 226030, Uttar Pradesh, India

Abhishek Kumar, Department of Anaesthesia, King George Medical University, Lucknow 226003, Uttar Pradesh, India

Co-first authors: Chandra K Pandey and Abhishek Kumar.

Author contributions: Pandey CK and Kumar A contributed to writing and editing the manuscript, illustrations, and review of the literature, contributed equally to this article, and are co-first authors of this manuscript; Pandey CK designed the overall concept and outline of the manuscript; Kumar A contributed to the discussion and design of the manuscript; All authors thoroughly reviewed and endorsed the final manuscript.

Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Chandra K Pandey, MD, Professor, Department of Anaesthesiology, Medanta Hospital Lucknow, Sultanpur Road, Lucknow 226030, Uttar Pradesh, India. ceekeypandey@gmail.com

Received: August 7, 2024
Revised: December 21, 2024
Accepted: January 2, 2025
Published online: March 27, 2025
Processing time: 200 Days and 12.6 Hours

Core Tip

Core Tip: Dexmedetomidine (Dex) is a significant drug that improves surgical outcomes in varied surgeries. The neuroprotective, opioid-sparing, and sympatholytic properties of Dex have shown improved outcomes in the elderly population in various surgeries including radical colon surgeries. The decline in the incidence and severity of postoperative cognitive dysfunction, the decreased surge in proinflammatory markers, improved regional cerebral oxygenation, and better pain control due to Dex lead to improved outcomes, early discharge, and decreased healthcare costs in this vulnerable group of patients.