Value of brief hematological characteristics in differentiating carcinoembryonic-antigen-negative colorectal cancer from benign colorectal diseases

doi:10.4240/wjgs.v17.i2.101403

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastrointest Surg. Feb 27, 2025; 17(2): 101403
Published online Feb 27, 2025. doi: 10.4240/wjgs.v17.i2.101403

Value of brief hematological characteristics in differentiating carcinoembryonic-antigen-negative colorectal cancer from benign colorectal diseases

Li-Ling Yi, Xian-Jun Lao, Liu-Yi Lu, Chun-Ling Zhu, Dong-Yi Zhou, Si-Ting Li, Meng-Li Fan, Qi-Liu Peng

Li-Ling Yi, Liu-Yi Lu, Chun-Ling Zhu, Dong-Yi Zhou, Si-Ting Li, Meng-Li Fan, Qi-Liu Peng, Department of Clinical Laboratory, Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530201, Guangxi Zhuang Autonomous Region, China

Xian-Jun Lao, Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, Nanning 530021, Guangxi Zhuang Autonomous Region, China

Co-first authors: Li-Ling Yi and Xian-Jun Lao.

Author contributions: Yi LL and Lao XJ designed, wrote and reviewed the manuscript; Lu LY and Zhu CL analyzed the data; Zhou DY, Li ST and Fan ML collected the data; Peng QL guided the study; All authors reviewed, edited, and approved the final manuscript and revised it critically for important intellectual content, gave final approval of the version to be published, and agreed to be accountable for all aspects of the work.

Supported by Youth Project of Guangxi International Zhuang Medicine Hospital, No. [2022]203; Discipline Project of Guangxi International Zhuang Medicine Hospital, No. [2021]33; and Research Fund of Guangxi International Zhuang Medicine Hospital, No. RCYJ202201.

Institutional review board statement: The study was reviewed and approved by the Guangxi International Zhuang Medicine Hospital Institutional Review Board (Approval No. 2022-047-01).

Informed consent statement: The Institutional Review Board waived the requirement for informed consent.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: The data used in this study were shared without the consent of the participants, but the data provided have been anonymized and can be requested from the corresponding author (pengql45@163.com) if there is a valid reason for needing them.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Qi-Liu Peng, PhD, Professor, Department of Clinical Laboratory, Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine, No. 8 Qiuyue Road, Liangqing District, Nanning 530201, Guangxi Zhuang Autonomous Region, China. pengql45@163.com

Received: September 13, 2024
Revised: November 7, 2024
Accepted: December 3, 2024
Published online: February 27, 2025
Processing time: 131 Days and 5.5 Hours

Core Tip

Core Tip: A retrospective analysis was used to investigate the hematological characteristics of carcinoembryonic-antigen (CEA)-negative colorectal cancer (CRC) with the aim of identifying potentially valuable biomarkers for distinguishing between CEA-negative CRC and benign colorectal diseases. We found that hematological parameters were associated with CEA-negative CRC and benign colorectal diseases. Moreover, hematological ratios were related to clinicopathological features of CEA-negative CRC. The results suggest that hemoglobin-to-red blood cell distribution width ratio, lymphocyte-to-red blood cell distribution width ratio, and platelet-to-lymphocyte ratio either individually or in combination could effectively differentiate CEA-negative CRC from benign colorectal diseases.