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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2025; 17(12): 112256
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.112256
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.112256
Effect of perioperative glutamine-enriched nutritional support on patients with colorectal cancer: A systematic review and meta-analysis
Yong Huang, Xiu-Zhi Yang, Song-Han Qin, Tao Zhang, Ming Xie, Ji-Wei Wang, Department of General Surgery, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Yong Huang, Xiu-Zhi Yang, Song-Han Qin, Tao Zhang, Ming Xie, Ji-Wei Wang, Guizhou Provincial Key Laboratory of Digestive Disease, Zunyi 563000, Guizhou Province, China
Author contributions: Huang Y and Yang XZ participated in the database searches, screening, data extraction; Qin SH and Zhang T assessed the quality of the studies; Huang Y analyzed the data and wrote the manuscript; Xie M and Wang JW reviewed and calibrated the manuscript. All authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81960105; and Medical Research Union Fund for High-quality Health Development of Guizhou Province, No. 2024GZYXKYJJXM0155.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ji-Wei Wang, Department of General Surgery, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, No. 140 Dalian Road, Huichuan District, Zunyi 563000, Guizhou Province, China. jiwei_wang@zmu.edu.cn
Received: July 22, 2025
Revised: August 28, 2025
Accepted: October 20, 2025
Published online: December 27, 2025
Processing time: 156 Days and 5.4 Hours
Revised: August 28, 2025
Accepted: October 20, 2025
Published online: December 27, 2025
Processing time: 156 Days and 5.4 Hours
Core Tip
Core Tip: Our study found that glutamine (Gln) supplementation could not only effectively improve the postoperative nutritional status, reduce the incidence of postoperative complications and shorten the length of hospital stay, but also, importantly, maintain nitrogen balance, enhance immune function and reduce inflammation levels of colorectal cancer (CRC) patients, without the interference of comorbidities and other immune nutrients. On the basis of previous studies, this further confirmed that perioperative application of Gln can bring positive prognosis to CRC patients, and provided an evidence-based basis for the widespread clinical application of Gln.