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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2025; 17(12): 112038
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.112038
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.112038
Analysis of antinuclear antibody pattern distribution and correlation in patients with colorectal cancer
Zi-Zhen Liang, Jin-Hua He, Ze-Ping Han, Xiao-Yan Yang, Li-Yin Liao, Department of Laboratory Medicine, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou 511400, Guangdong Province, China
Author contributions: Liang ZZ designed the research and wrote the first manuscript; Liang ZZ, He JH and Han ZP contributed to conceiving the research and analyzing data; Liang ZZ, Yang XY and Liao LY conducted the analysis; Liao LY provided guidance for the research; all authors reviewed and approved the final manuscript.
Supported by Panyu District Science and Technology Plan Project, No. 2024-Z04-012.
Institutional review board statement: This study was approved by The Affiliated Panyu Central Hospital, Guangzhou Medical University, approval No. PYRC-2025-031-01.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There is no conflict of interest.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: All data and materials are available from the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zi-Zhen Liang, Deputy Chief Technician, Department of Laboratory Medicine, The Affiliated Panyu Central Hospital, Guangzhou Medical University, No. 8 Fuyu East Road, Qiaonan Street, Panyu, Guangzhou 511400, Guangdong Province, China.
Received: August 26, 2025
Revised: October 8, 2025
Accepted: October 31, 2025
Published online: December 27, 2025
Processing time: 120 Days and 18.1 Hours
Revised: October 8, 2025
Accepted: October 31, 2025
Published online: December 27, 2025
Processing time: 120 Days and 18.1 Hours
Core Tip
Core Tip: Antinuclear antibodies (ANAs), also known as antinuclear factors, were first identified in cases of systemic lupus erythematosus. ANA testing enhances the diagnostic accuracy of immune-mediated diseases and demonstrates high specificity. Colorectal cancer (CRC) is one of the most common malignant neoplasms worldwide, with incidence rates in China continuing to rise. Autoantibodies are increasingly recognized as tumor markers, offering greater specificity than conventional markers and enabling earlier detection. In this study, indirect immunofluorescence was used to detect ANA fluorescence patterns in CRC and explore their correlation.