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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2025; 17(12): 111268
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.111268
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.111268
Endoscopic hemostasis combined with vascular interventional therapy for acute nonvariceal upper gastrointestinal bleeding: A meta-analysis
Cun-Jin Zhou, Hui Sun, Xiao-He Tang, Department of Gastroenterology, The First Hospital of Zibo, Zibo 255200, Shandong Province, China
Co-first authors: Cun-Jin Zhou and Hui Sun.
Author contributions: Zhou CJ and Sun H contributed equally to this work and are co-first authors; Zhou CJ performed the research and wrote the paper; Sun H performed the research, acquired, and analyzed the data; Tang XH interpreted the data and revised the article; and all authors edited and approved the final version of the article.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-He Tang, Department of Gastroenterology, The First Hospital of Zibo, No. 4 Emeishan East Alley, Boshan, Zibo 255200, Shandong Province, China.
Received: August 1, 2025
Revised: September 10, 2025
Accepted: October 17, 2025
Published online: December 27, 2025
Processing time: 145 Days and 18.7 Hours
Revised: September 10, 2025
Accepted: October 17, 2025
Published online: December 27, 2025
Processing time: 145 Days and 18.7 Hours
Core Tip
Core Tip: This meta-analysis demonstrates that combining endoscopic hemostasis with vascular interventional therapy is effective for acute nonvariceal upper gastrointestinal bleeding, significantly reducing rebleeding rates versus standard therapy. While it shows no significant differences in initial hemostasis success or mortality, mortality findings require further validation. These results aid clinical treatment optimization, though subgroup effects related to age and intervention methods need deeper investigation.