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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2025; 17(12): 111221
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.111221
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.111221
Correlation of hypercalcemia with kidney stone formation and calcium-regulating hormone changes in patients with acute pancreatitis
Shun-Ping Wang, You-Feng Zhou, Chun-Bo Tang, Shuai-Shuai Huang, Yong Zhou, Zi-Pei Cao, Wei Chen, Department of Urology, Ningbo Urology and Nephrology Hospital, Ningbo 315100, Zhejiang Province, China
Author contributions: Wang SP and Tang CB proposed the concept of this study; Tang CB participated in data collection; Wang SP wrote the initial draft; Chen W, Huang SS, and Zhou Y contributed to the formal analysis of this study; Cao ZP and Zhou Y guided the research, methodology, and visualization of the manuscript; Wang SP, Chen W, Tang CB, Huang SS, and Cao ZP participated in the study, validated the results, and jointly reviewed and edited the manuscript. All authors approved the final version to publish.
Supported by Zhejiang Province Medical and Health Science and Technology Program Project, No. 2021KY1067.
Institutional review board statement: This study was approved and reviewed by the Ethics Committee of Ningbo Urology and Kidney Disease Hospital, No. 2020-214-01(z).
Informed consent statement: Informed consent forms signed by the patients and their guardians were obtained for this study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No available data.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Chen, MD, Associate Chief Physician, Department of Urology, Ningbo Urology and Nephrology Hospital, No. 1 Qianhe North Road, Yinzhou District, Ningbo 315100, Zhejiang Province, China. chenweikhm@126.com
Received: July 29, 2025
Revised: August 21, 2025
Accepted: October 22, 2025
Published online: December 27, 2025
Processing time: 148 Days and 17.9 Hours
Revised: August 21, 2025
Accepted: October 22, 2025
Published online: December 27, 2025
Processing time: 148 Days and 17.9 Hours
Core Tip
Core Tip: This study aimed to examine the relationship between hypercalcemia and kidney stone formation in patients with acute pancreatitis. Of the 200 patients, 35% developed kidney stones, with a significant correlation between hypercalcemia and stone formation (P < 0.001). Notably, elevated parathyroid hormone levels were observed in 60% of patients with hypercalcemia, underscoring the complex interactions between calcium metabolism and renal complications in acute pancreatitis. Understanding these relationships is essential for enhancing management strategies and improving clinical outcomes.