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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Nov 27, 2025; 17(11): 112729
Published online Nov 27, 2025. doi: 10.4240/wjgs.v17.i11.112729
Published online Nov 27, 2025. doi: 10.4240/wjgs.v17.i11.112729
Risk factors for esophageal pain after peroral endoscopic myotomy under general anesthesia: A retrospective study
Jia-Wei Yin, Han Xu, Ting-Ting Wen, Sheng-Wen Song, Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
Wen-Qi Zhang, Department of Anesthesiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
Author contributions: Yin JW and Song SW designed the research; Yin JW, Xu H and Song SW managed the clinical process; Yin JW collected clinical data; Yin JW and Song SW wrote the manuscript; Zhang WQ, Wen TT and Song SW revised the manuscript. All the authors have read and approved the final manuscript.
Supported by the Special Research Project on Optimal Management of Acute Pain, Wu Jie-ping Medical Foundation, No. 320.6750.2024-15.101.
Institutional review board statement: The study protocol was approved by the Ethics Committee of The First Affiliated Hospital, Zhejiang University School of Medicine ([2025B] IIT Ethics Approval No. 0707) and was registered with the Chinese Clinical Trial Registry (https://www.chictr.org.cn/Registration number: ChiCTR2500104753). All the data were anonymized to protect patient privacy.
Informed consent statement: This study was reviewed and approved by the Ethics Committee for Investigator-Initiated Clinical Trials of the First Affiliated Hospital, Zhejiang University School of Medicine. Additionally, the requirement for obtaining informed consent from participants was formally waived by the committee.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request. The data are not publicly available because of privacy or ethical restrictions.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work noncommercially, and license their derivative works on different terms, provided the original work is properly cited and the use is noncommercial. See: https://creativecommons.org/Licenses/bync/4.0/
Corresponding author: Sheng-Wen Song, MD, Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 1367 Wenyi West Road, Hangzhou 310000, Zhejiang Province, China. songsheng_wen@126.com
Received: August 5, 2025
Revised: September 6, 2025
Accepted: October 11, 2025
Published online: November 27, 2025
Processing time: 112 Days and 13.5 Hours
Revised: September 6, 2025
Accepted: October 11, 2025
Published online: November 27, 2025
Processing time: 112 Days and 13.5 Hours
Core Tip
Core Tip: This study revealed that the incidence of postoperative pain in patients with achalasia who underwent peroral endoscopic esophageal myotomy (POEM) significantly increased, with 26.8% of patients experiencing at least moderate-intensity pain (numerical rating scale score ≥ 4). Furthermore, preoperative anxiety and a high Eckardt score were independent risk factors for post-POEM pain. These findings suggest that incorporating clinical symptom assessment, psychological status screening, and optimized analgesic strategies into preoperative anesthesia management is crucial for preventing and relieving postoperative pain.