©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Nov 27, 2025; 17(11): 112204
Published online Nov 27, 2025. doi: 10.4240/wjgs.v17.i11.112204
Published online Nov 27, 2025. doi: 10.4240/wjgs.v17.i11.112204
Pancreatogenic diabetes: Pathophysiology, diagnosis, and management challenges
Duo Wang, Department of Recovery Room, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Yan Jiao, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Jiao Y contributed to the study design, literature review, and revisions of the final manuscript; Wang D wrote the initial draft; all authors approved the final version to be published.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Yan Jiao, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. lagelangri1@126.com
Received: July 21, 2025
Revised: August 7, 2025
Accepted: September 24, 2025
Published online: November 27, 2025
Processing time: 127 Days and 23.1 Hours
Revised: August 7, 2025
Accepted: September 24, 2025
Published online: November 27, 2025
Processing time: 127 Days and 23.1 Hours
Core Tip
Core Tip: Pancreatogenic diabetes is a distinct form of diabetes that results from pancreatic dysfunction, commonly seen in chronic pancreatitis and pancreatic cancer. Accurate diagnosis requires a comprehensive approach involving clinical history, imaging, and biochemical markers. Treatment typically includes insulin therapy, pancreatic enzyme replacement, and nutritional support. Given the association with pancreatic cancer, ongoing surveillance and early detection in high-risk groups are essential. Standardized diagnostic criteria and evidence-based treatment guidelines are urgently needed to improve patient care.