©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Nov 27, 2025; 17(11): 111404
Published online Nov 27, 2025. doi: 10.4240/wjgs.v17.i11.111404
Published online Nov 27, 2025. doi: 10.4240/wjgs.v17.i11.111404
Recurrent and chronic appendicitis: Diagnostic challenges and clinical insights
Steven H Yale, Department of Internal Medicine, University of Central Florida, Orlando, FL 32827, United States
Halil Tekiner, Department of the History of Medicine and Ethics, Erciyes University School of Medicine, Melikgazi 38039, Kayseri, Türkiye
Eileen S Yale, Department of Medicine, NSU Medical School, Fort Lauderdale, FL 33328, United States
Author contributions: Yale SH, Tekiner H, and Yale ES were involved in conceptualizing, drafting, and revising of the manuscript. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Steven H Yale, MD, Full Professor, Department of Internal Medicine, University of Central Florida, 6850 Lake Nona Blvd, Orlando, FL 32827, United States.
Received: June 30, 2025
Revised: July 22, 2025
Accepted: September 4, 2025
Published online: November 27, 2025
Processing time: 149 Days and 23 Hours
Revised: July 22, 2025
Accepted: September 4, 2025
Published online: November 27, 2025
Processing time: 149 Days and 23 Hours
Core Tip
Core Tip: Diagnosing recurrent and chronic appendicitis poses significant clinical challenges. It requires a clear understanding of pathophysiological mechanisms, precise case definitions, and detailed patient history and physical examination. Employing these approaches, supplemented by imaging studies, enhances diagnostic accuracy. Surgeons should avoid operating without a definitive diagnosis to prevent unnecessary in